ArticleProceedings of the National Academy of Sciences of the United States of America2007
GSTpi expression mediates dopaminergic neuron sensitivity in experimental parkinsonism.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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Who cites it
36 citing papers in PubMed, 76 citations in OpenAlex.
- Tat-GSTpi Inhibits Dopaminergic Cells against MPPBiomedicines · 2023Article
- Glutathione S-transferases Control astrocyte activation and neuronal health during neuroinflammation.Frontiers in molecular biosciences · 2022Article
- In vitro inhibition of glutathione-S-transferase by dopamine and its metabolites, 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetic acid.Neurotoxicology · 2021Article
- Effect of Chronic Methylphenidate Treatment in a Female Experimental Model of Parkinsonism.Neurotoxicity research · 2021Article
- GlutathioneScience signaling · 2019Article
- Inhibition of glutathione S-transferase-pi triggers c-jun N-terminal kinase-dependent neuronal death in Zn-induced Parkinsonism.Molecular and cellular biochemistry · 2019Article
- Astrocytes Surviving Severe Stress Can Still Protect Neighboring Neurons from Proteotoxic Injury.Molecular neurobiology · 2016Article
- Article
- The Genetic Architecture of Murine Glutathione Transferases.PloS one · 2016Article
- Protection of HepG2 cells against acrolein toxicity by 2-cyano-3,12-dioxooleana-1,9-dien-28-imidazolide via glutathione-mediated mechanism.Experimental biology and medicine (Maywood, N.J.) · 2015Article
- HIF1α is necessary for exercise-induced neuroprotection while HIF2α is needed for dopaminergic neuron survival in the substantia nigra pars compacta.Neuroscience · 2015Article
- Acute Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or Paraquat on Core Temperature in C57BL/6J Mice.Journal of Parkinson's disease · 2015Article
- Neurochemical measurement of adenosine in discrete brain regions of five strains of inbred mice.PloS one · 2014Article
- Association of glutathione S-transferase P1 (GSTP1) polymorphism with Tourette syndrome in Taiwanese patients.Genetic testing and molecular biomarkers · 2014Article
- Glutathione metabolism and Parkinson's disease.Free radical biology & medicine · 2013Review
- The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism.Neurotoxicology · 2013Article
- Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice.Molecular neurobiology · 2013Article
- Thiol-redox signaling, dopaminergic cell death, and Parkinson's disease.Antioxidants & redox signaling · 2012Review
- Glutathione S-transferase pi mediates MPTP-induced c-Jun N-terminal kinase activation in the nigrostriatal pathway.Molecular neurobiology · 2012Article
- Pharmacological manipulation of peroxisome proliferator-activated receptor γ (PPARγ) reveals a role for anti-oxidant protection in a model of Parkinson's disease.Experimental neurology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
The cause of 95% of Parkinson's disease (PD) cases is unknown. It is hypothesized that PD arises from an interaction of free-radical-generating agents with an underlying genetic susceptibility to these compounds. Here we use the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of parkinsonism to examine the role of a dual function protein, GSTpi, in dopaminergic neuron death. GSTpi is the only GST family member expressed in substantia nigra neurons. GSTpi reduction by pharmacological blockade, RNA inhibition, and gene targeting increases sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, suggesting that differential expression of GSTpi contributes to the sensitivity to xenobiotics in the substantia nigra and may influence the pathogenesis of reactive oxygen species-induced neurological disorders including PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.