ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Acute hypoxia activates the neuroimmune system, which diabetes exacerbates.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Systems-level insights into bronchopulmonary dysplasia from meta-analysis of genome-scale studies.Respiratory research · 2026Pooled it
- Transcriptomic profiling and targeted validation reveal molecular mechanisms of oxygen therapy in high-altitude cerebral injury.Frontiers in neuroscience · 2026Article
- Dysregulated Neuroimmune and Anhedonia-Like Behavioral Response Following Peripheral Immune Challenge in Mice Carrying the Val66Met Brain-Derived Neurotrophic Factor Polymorphism.Psychiatry international · 2025Article
- Mouse Testing Methods in Psychoneuroimmunology: Measuring Behavioral Responses.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Memory Function, Neurological, and Immunological Biomarkers in Allergic Asthmatic Mice Intratracheally Exposed to Bisphenol A.International journal of environmental research and public health · 2019Article
- Handling stress impairs learning through a mechanism involving caspase-1 activation and adenosine signaling.Brain, behavior, and immunity · 2019Article
- Switching from a high-fat cellulose diet to a high-fat pectin diet reverses certain obesity-related morbidities.Nutrition & metabolism · 2018Article
- Acute fasting inhibits central caspase-1 activity reducing anxiety-like behavior and increasing novel object and object location recognition.Metabolism: clinical and experimental · 2017Article
- Modulation of neuroimmunity by adenosine and its receptors: metabolism to mental illness.Metabolism: clinical and experimental · 2014Review
- Adenosine through the A2A adenosine receptor increases IL-1β in the brain contributing to anxiety.Brain, behavior, and immunity · 2014Article
- Reconceptualizing major depressive disorder as an infectious disease.Biology of mood & anxiety disorders · 2014Article
- IL-1 receptor 2 (IL-1R2) and its role in immune regulation.Brain, behavior, and immunity · 2013Review
- Cobalt Chloride-induced Hypoxia Ameliorates NLRP3-Mediated Caspase-1 Activation in Mixed Glial Cultures.Immune network · 2013Article
- Hypoxia/reoxygenation impairs memory formation via adenosine-dependent activation of caspase 1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Individually ventilated cages cause chronic low-grade hypoxia impacting mice hematologically and behaviorally.Brain, behavior, and immunity · 2012Article
- Differential effects of acute hypoxia on the activation of TRPV1 by capsaicin and acidic pH.The journal of physiological sciences : JPS · 2012Article
- The biobehavioral and neuroimmune impact of low-dose ionizing radiation.Brain, behavior, and immunity · 2012Article
- Fasting induces an anti-inflammatory effect on the neuroimmune system which a high-fat diet prevents.Obesity (Silver Spring, Md.) · 2011Article
- Sickness behavior induced by endotoxin can be mitigated by the dietary soluble fiber, pectin, through up-regulation of IL-4 and Th2 polarization.Brain, behavior, and immunity · 2010Article
- Accelerated recovery from acute hypoxia in obese mice is due to obesity-associated up-regulation of interleukin-1 receptor antagonist.Endocrinology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Acute hypoxia is experienced in an array of ailments and conditions, including asthma, chronic obstructive pulmonary disease, heart failure, sleep apnea, acute hypotension, and blast lung injury. Classically, infection activates the neuroimmune system, causing loss of interest in the social environment. We report that the non-infectious stimulus acute hypoxia triggers neuroimmune system activation (NSA), causing loss of interest in the social environment, and that recovery from hypoxia-induced NSA is impaired in a mouse model of type 2 diabetes. Importantly, recovery from the behavioral consequences of hypoxia-induced NSA was nearly ablated in MyD88 (myeloid differentiation factor 88) knock-out mice and in mice intracerebroventricularly administered the caspase-1 inhibitor ac-YVAD-CMK (ac-Tyr-Val-Asp-2,6-dimethylbenzoyloxymethylketone). Diabetic mice had prolonged recovery from NSA that could be halved by administration of subcutaneous interleukin-1 (IL-1) receptor antagonist (RA). These results show that acute hypoxia activates the IL-1beta arm of the neuroimmune system, which diabetes exacerbates and treatment with IL-1RA ameliorates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.