The principles of weight of evidence validation of test methods and testing strategies. The report and recommendations of ECVAM workshop 58.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. A Systematic Review to Compare Chemical Hazard Predictions of the Zebrafish Embryotoxicity Test With Mammalian Prenatal Developmental Toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2021
   Pooled it
2. Next generation validation for next generation risk assessment.Frontiers in toxicology · 2026
   Review
3. Adaptation of the Systematic Review Framework to the Assessment of Toxicological Test Methods: Challenges and Lessons Learned With the Zebrafish Embryotoxicity Test.Toxicological sciences : an official journal of the Society of Toxicology · 2019
   Article
4. From "weight of evidence" to quantitative data integration using multicriteria decision analysis and Bayesian methods.ALTEX · 2015
   Article
5. Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology.Reproductive toxicology (Elmsford, N.Y.) · 2013
   Review
6. Integrated testing strategies for safety assessments.ALTEX · 2013
   Article
7. Basic data on the hematology, serum biochemistry, urology, and organ weights of beagle dogs.Laboratory animal research · 2011
   Article
8. Toxicity testing in the 21st century: a vision and a strategy.Journal of toxicology and environmental health. Part B, Critical reviews · 2010
   Article
9. A toxicology for the 21st century--mapping the road ahead.Toxicological sciences : an official journal of the Society of Toxicology · 2009
   Article
10. Animal use in pharmacology education and research: the changing scenario.Indian journal of pharmacology
    Review
11. Validating and troubleshooting ocular in vitro toxicology tests.Journal of pharmacological and toxicological methods
    Review

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

23 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as