ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life2007
Kinetic analysis of oligo(C) formation from the 5'-monophosphorimidazolide of cytidine with Pb(II) ion catalyst at 10-75 degrees C.
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Protocellular energy transduction, information and fitness.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Cascade of reduced speed and accuracy after errors in enzyme-free copying of nucleic acid sequences.Journal of the American Chemical Society · 2013Article
- Behavior of a hammerhead ribozyme in aqueous solution at medium to high temperatures.Die Naturwissenschaften · 2012Article
- Creating prebiotic sanctuary: self-assembling supramolecular Peptide structures bind and stabilize RNA.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2011Article
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Abstract
The temperature dependence of the rate constants for the formation of oligocytidylate (oligo(C)) from the 5'-monophosphorimidazolide of cytidine (ImpC) in the presence of Pb(II) ion catalyst has been investigated at 10-75 degrees C. The rate constants for the formation of oligo(C) increased in the order of the formation of 2-mer < 3-mer < or = 4-mer; this trend resembles the trend in the cases of the template-directed and the clay-catalyzed formations of oligonucleotides. While the rate constants of the formation of oligo(C) increased with increasing temperature, the yield of oligo(C) decreased with increasing temperature. This is due to the fact that the relative magnitude of the rate constants of the formation of 2-mer, 3-mer, and 4-mer to that of the hydrolysis of ImpC decreased with increasing temperature. This is probably due to the fact that association between ImpC with the elongating oligo(C) decreases with increasing temperature. The apparent activation energy was 61.9 +/- 8.5 kJ mol(-1) for the formation of 2-mer, 49.3 +/- 2.9 kJ mol(-1) for 3-mer, 51.8 kJ mol(-1) for 4-mer, and 66.8 +/- 4.5 kJ mol(-1) for the hydrolysis of ImpC. The significance of the temperature dependence of the formation rate constants of the model prebiotic formation of RNA is discussed.
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