Evidence map›Paper›PMID 17264486›Full record

ReviewChemical immunology and allergy2007

Major histocompatibility complex molecules on parenchymal cells of the target organ protect against autoimmune disease.

Hui Shao, Henry J Kaplan, Deming Sun

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chemical immunology and allergy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hui ShaoDepartment of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, Ky., USA.
Henry J Kaplan
Deming Sun
University of Louisville · US

Funding

The Roles of Costimulatory Molecules in EAAUR01EY012974 · NEI · UNIVERSITY OF LOUISVILLE · PI SHAO, HUI · 2001 to 2011
$2.6M
Progression of Uveitis and CD8 uveitogenic T cellsR01EY017373 · NEI · UNIVERSITY OF LOUISVILLE · PI SUN, DEMING · 2007 to 2011
$1.5M
Characterization of uveitogenic T cellsR01EY014366 · NEI · UNIVERSITY OF LOUISVILLE · PI SUN, DEMING · 2003 to 2007
$1.5M
Vision Research Infrastructure DevelopmentR24EY015636 · NEI · UNIVERSITY OF LOUISVILLE · PI KAPLAN, HENRY JERROLD · 2004 to 2008
$1.0M
Regulation of the Ocular Immune Response by RPE.R01EY014599 · NEI · UNIVERSITY OF LOUISVILLE · PI SHAO, HUI · 2004 to 2007
$1.0M
NEI NIH HHS EY014366NEI NIH HHS EY12974NEI NIH HHS EY14599NEI NIH HHS R01 EY012974NEI NIH HHS R01 EY014366NEI NIH HHS R01 EY014599NEI NIH HHS R01 EY017373NEI NIH HHS R24 EY015636
6 · The paper itself

Abstract

Parenchymal cells of the autoimmune organ may only express major histocompatibility complex (MHC) molecules during the disease process. In this paper, we hypothesize that the appearance of MHC molecules on parenchymal cells may augment the activation of invading autoreactive T cells and either exacerbate or suppress local inflammation. It is speculated that like many biological responses this is a two-edge sword - namely, the expression of modest levels of MHC molecules may inhibit the activation of invading T cells, whereas overexpression of these molecules may promote activation of autoimmune T cells, enhancing the inflammatory cascade, thus leading to tissue damage.

Indexed as

Adoptive TransferAmino Acid SequenceAnimalsAutoimmune DiseasesHistocompatibility Antigens Class IIHumansLymphocyte ActivationMolecular Sequence DataPigment Epithelium of EyeT-LymphocytesUveitisHistocompatibility Antigens Class II

Identifiers

PMID17264486
PMCPMC2951609
OpenAlexW1555808286

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.