ArticleNucleic acids research2007
Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Trial
- Chromatin interaction landscape of epimorphic regeneration in teleost fish.Science advances · 2026Article
- The SUMO Family: Mechanisms and Implications in Thyroid Cancer Pathogenesis and Therapy.Biomedicines · 2024Review
- SUMOylation mediates the disassembly of the Smad4 nuclear export complex via RanGAP1 in KELOIDS.Journal of cellular and molecular medicine · 2023Article
- ATF7-dependent epigenetic changes induced by high temperature during early porcine embryonic development.Cell proliferation · 2023Article
- SUMO and Transcriptional Regulation: The Lessons of Large-Scale Proteomic, Modifomic and Genomic Studies.Molecules (Basel, Switzerland) · 2021Review
- Regulation of transcription factors by sumoylation.Transcription · 2017Review
- ATF7 is stabilized during mitosis in a CDK1-dependent manner and contributes to cyclin D1 expression.Cell cycle (Georgetown, Tex.) · 2015Article
- Sumo and the cellular stress response.Cell division · 2015Review
- Profiling status epilepticus-induced changes in hippocampal RNA expression using high-throughput RNA sequencing.Scientific reports · 2014Article
- Insertional hypermutation in mineral oil-induced plasmacytomas.European journal of immunology · 2014Article
- Article
- SUMOhunt: Combining Spatial Staging between Lysine and SUMO with Random Forests to Predict SUMOylation.ISRN bioinformatics · 2013Article
- Sumoylation is important for stability, subcellular localization, and transcriptional activity of SALL4, an essential stem cell transcription factor.The Journal of biological chemistry · 2012Article
- Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation.The Journal of biological chemistry · 2012Article
- SUMOylation represses Nanog expression via modulating transcription factors Oct4 and Sox2.PloS one · 2012Article
- A cytoplasmic negative regulator isoform of ATF7 impairs ATF7 and ATF2 phosphorylation and transcriptional activity.PloS one · 2011Article
- A manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics.International journal of biological sciences · 2010Review
- Article
- ATF2 on the double - activating transcription factor and DNA damage response protein.Pigment cell research · 2007Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past few years, small ubiquitin-like modifier (SUMO) modification has emerged as an important regulator of diverse pathways and activities including protein localization and transcriptional regulation. We identified a consensus sumoylation motif (IKEE), located within the N-terminal activation domain of the ATF7 transcription factor and thus investigated the role of this modification. ATF7 is a ubiquitously expressed transcription factor, homologous to ATF2, that binds to CRE elements within specific promoters. This protein is able to heterodimerize with Jun or Fos proteins and its transcriptional activity is mediated by interaction with TAF12, a subunit of the general transcription factor TFIID. In the present article, we demonstrate that ATF7 is sumoylated in vitro (using RanBP2 as a E3-specific ligase) and in vivo. Moreover, we show that ATF7 sumoylation affects its intranuclear localization by delaying its entry into the nucleus. Furthermore, SUMO conjugation inhibits ATF7 transactivation activity by (i) impairing its association with TAF12 and (ii) blocking its binding-to-specific sequences within target promoters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.