ArticleNucleic acids research2007
Raman and Raman optical activity (ROA) analysis of RNA structural motifs in Domain I of the EMCV IRES.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
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- Nucleic Acid-Rich Stress Granules Are Not Merely Crowded Condensates: A Quantitative Raman Imaging Study.Analytical chemistry · 2024Article
- Plasma-derived extracellular vesicles (EVs) as biomarkers of sepsis in burn patients via label-free Raman spectroscopy.Journal of extracellular vesicles · 2024Article
- Label-free morpho-molecular phenotyping of living cancer cells by combined Raman spectroscopy and phase tomography.Communications biology · 2024Article
- Evaluation ofDentistry journal · 2024Article
- Plasma-derived Extracellular Vesicles (EVs) as Biomarkers of Sepsis in Burn Patients via Label-free Raman Spectroscopy.bioRxiv : the preprint server for biology · 2024Article
- Direct imaging of intracellular RNA, DNA, and liquid-liquid phase separated membraneless organelles with Raman microspectroscopy.Communications biology · 2022Article
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- Strategies and Perspectives for UV Resonance Raman Applicability in Clinical Analyses of Human Sperm RNA.International journal of molecular sciences · 2021Article
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- Stability of β-lactam antibiotics in bacterial growth media.PloS one · 2020Article
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- Engaging with Raman Spectroscopy to Investigate Antibody Aggregation.Antibodies (Basel, Switzerland) · 2018Review
- Two half-sandwiched ruthenium (II) compounds containing 5-fluorouracil derivatives: synthesis and study of DNA intercalation.PloS one · 2015Article
- Raman spectroscopic signatures of echovirus 1 uncoating.Journal of virology · 2014Article
- Raman characterization of Avocado Sunblotch viroid and its response to external perturbations and self-cleavage.BMC biophysics · 2014Article
- Hydrophobic properties of tRNA with varied conformations evaluated by an aqueous two-phase system.International journal of biological sciences · 2012Article
- Nonlinear optical imaging and Raman microspectrometry of the cell nucleus throughout the cell cycle.Biophysical journal · 2010Article
- Evaluation of Escherichia coli cell response to antibiotic treatment by use of Raman spectroscopy with laser tweezers.Journal of clinical microbiology · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Raman and Raman optical activity (ROA) spectra were collected for four RNA oligonucleotides based on the EMCV IRES Domain I to assess the contributions of helix, GNRA tetraloop, U.C mismatch base pair and pyrimidine-rich bulge structures to each. Both Raman and ROA spectra show overall similarities for all oligonucleotides, reflecting the presence of the same base paired helical regions and GNRA tetraloop in each. Specific bands are sensitive to the effect of the mismatch and asymmetric bulge on the structure of the RNA. Raman band changes are observed that reflect the structural contexts of adenine residues, disruption of A-form helical structure, and incorporation of pyrimidine bases in non-helical regions. The ROA spectra are also sensitive to conformational mobility of ribose sugars, and verify a decrease in A-type helix content upon introduction of the pyrimidine-rich bulge. Several Raman and ROA bands also clearly show cooperative effects between the mismatch and pyrimidine-rich bulge motifs on the structure of the RNA. The complementary nature of Raman and ROA spectra provides detailed and highly sensitive information about the local environments of bases, and secondary and tertiary structures, and has the potential to yield spectral signatures for a wide range of RNA structural motifs.
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