ArticleBMC cancer2007
Hyperoxia retards growth and induces apoptosis and loss of glands and blood vessels in DMBA-induced rat mammary tumors.
Article in BMC cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 79 citations in OpenAlex.
- Hyperbaric Oxygen Therapy for Managing Cancer Treatment Complications: A Safety Evaluation.Medicina (Kaunas, Lithuania) · 2025Article
- HBO regulates the Warburg effect of hypoxic HCC cells through miR-103a-3p/TRIM35.Discover oncology · 2024Article
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- Advances in hyperbaric oxygen to promote immunotherapy through modulation of the tumor microenvironment.Frontiers in oncology · 2023Review
- The Normobaric Oxygen Paradox-Hyperoxic Hypoxic Paradox: A Novel Expedient Strategy in Hematopoiesis Clinical Issues.International journal of molecular sciences · 2022Review
- Implications of Hyperoxia over the Tumor Microenvironment: An Overview Highlighting the Importance of the Immune System.Cancers · 2022Review
- Exploring Hyperoxia Effects in Cancer-From Perioperative Clinical Data to Potential Molecular Mechanisms.Biomedicines · 2021Review
- The anti-tumoral effects of the oxygen carrier YQ23 in a triple-negative breast cancer syngeneic model.Translational cancer research · 2021Article
- Role of hyperoxic treatment in cancer.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer.Nature cancer · 2020Article
- Deconvolution of RNA-Seq Analysis of Hyperbaric Oxygen-Treated Mice Lungs Reveals Mesenchymal Cell Subtype Changes.International journal of molecular sciences · 2020Article
- Article
- Overcoming hypoxia-induced chemoresistance to cisplatin through tumor oxygenation monitored by optical imaging.Nanotheranostics · 2019Article
- Article
- Combination of carboplatin and intermittent normobaric hyperoxia synergistically suppresses benzo[a]pyrene-induced lung cancer.The Korean journal of internal medicine · 2018Article
- Normobaric hyperoxia inhibits the progression of lung cancer by inducing apoptosis.Experimental biology and medicine (Maywood, N.J.) · 2018Article
- New Directions in the Study and Treatment of Metastatic Cancer.Frontiers in oncology · 2018Review
- Article
- HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels.Scientific reports · 2017Article
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Authors and funding
6 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study investigated the effects of hyperoxic treatment on growth, angiogenesis, apoptosis, general morphology and gene expression in DMBA-induced rat mammary tumors.
methodsOne group of animals was exposed to normobaric hyperoxia (1 bar, pO2 = 1.0 bar) and another group was exposed to hyperbaric hyperoxia (1.5 bar, pO2 = 1.5 bar). A third group was treated with the commonly used chemotherapeutic drug 5- Fluorouracil (5-FU), whereas animals housed under normal atmosphere (1 bar, pO2 = 0.2 bar) served as controls. All treatments were performed on day 1, 4, 7 and 10 for 90 min. Tumor growth was calculated from caliper measurements. Biological effects of the treatment, was determined by assessment of vascular morphology (immunostaining for von Willebrandt factor) and apoptosis (TUNEL staining). Detailed gene expression profiles were obtained and verified by quantitative rtPCR.
resultsTumor growth was significantly reduced (~57-66 %) after hyperoxic treatment compared to control and even more than 5-FU (~36 %). Light microscopic observations of the tumor tissue showed large empty spaces within the tissue after hyperoxic treatment, probably due to loss of glands as indicated by a strong down-regulation of glandular secretory proteins. A significant reduction in mean vascular density (30-50%) was found after hyperoxic treatment. Furthermore, increased apoptosis (18-21%) was found after hyperoxic treatment.
conclusionThus, by increasing the pO2 in mammary tumor tissue using normobaric and moderate hyperbaric oxygen therapy, a significant retardation in tumor growth is achieved, by loss of glands, reduction in vascular density and enhanced cell death. Hyperbaric oxygen should therefore be further evaluated as a tumor treatment.
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