ArticleOrganic letters2007
Synthesis of a 2'-Se-thymidine phosphoramidite and its incorporation into oligonucleotides for crystal structure study.
Article in Organic letters, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 57 citations in OpenAlex.
- Solid-phase synthesis and structural characterisation of phosphoroselenolate-modified DNA: a backbone analogue which does not impose conformational bias and facilitates SAD X-ray crystallography.Chemical science · 2019Article
- Construction and structure studies of DNA-bipyridine complexes as versatile scaffolds for site-specific incorporation of metal ions into DNA.Journal of biomolecular structure & dynamics · 2019Article
- Soaking Hexammine Cations into RNA Crystals to Obtain Derivatives for Phasing Diffraction Data.Methods in molecular biology (Clifton, N.J.) · 2016Article
- The importance of fitting in: conformational preference of selenium 2' modifications in nucleosides and helical structures.Journal of biomolecular structure & dynamics · 2015Article
- Synthesis and optical behaviors of 6-seleno-deoxyguanosine.Science China. Chemistry · 2014Article
- Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.Medicinal research reviews · 2013Review
- Synthesis of novel di-Se-containing thymidine and Se-DNAs for structure and function studies.Science China. Chemistry · 2013Article
- Hydrogen bond formation between the naturally modified nucleobase and phosphate backbone.Nucleic acids research · 2012Article
- Synthesis of the tellurium-derivatized phosphoramidites and their incorporation into DNA oligonucleotides.Current protocols in nucleic acid chemistry · 2011Article
- Facile synthesis of nucleoside 5'-(α-P-seleno)-triphosphates and phosphoroselenoate RNA transcription.RNA (New York, N.Y.) · 2011Article
- Synthesis of the 5'-Se-thymidine phosphoramidite and convenient labeling of DNA oligonucleotide.Organic letters · 2011Article
- Selenium derivatization of nucleic acids for phase and structure determination in nucleic acid X-ray crystallography.International journal of molecular sciences · 2008Article
- A general strategy to solve the phase problem in RNA crystallography.Structure (London, England : 1993) · 2007Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
[reaction: see text] To investigate nucleic acids with selenium derivatization for crystallography, we report the first synthesis of 2'-methylseleno-thymidine phosphoramidite and its incorporation into DNAs and RNAs by solid-phase synthesis with over 99% coupling yield. The d(GT(Se)GTACAC)2 crystal structure was also determined at 1.40 A resolution using Se phasing, revealing that this Se derivatization did not cause significant structure perturbation, consistent with our UV melting study. In addition, we observed that the Se modification largely facilitated the crystallization.
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