ArticleThe Journal of infectious diseases2007
Neonatal infection with G10P[11] rotavirus did not confer protection against subsequent rotavirus infection in a community cohort in Vellore, South India.
Article in The Journal of infectious diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Functional principal component analysis for identifying the child growth pattern using longitudinal birth cohort data.BMC medical research methodology · 2022Article
- A shift in circulating rotaviral genotypes among hospitalized neonates.Scientific reports · 2022Article
- Persistence of G10P[11] neonatal rotavirus infections in southern India.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2021Article
- Naturally Acquired Immunity Against Rotavirus Infection and Gastroenteritis in Children: Paired Reanalyses of Birth Cohort Studies.The Journal of infectious diseases · 2017Article
- Diversity in Rotavirus-Host Glycan Interactions: A "Sweet" Spectrum.Cellular and molecular gastroenterology and hepatology · 2016Review
- Correlates of protection against human rotavirus disease and the factors influencing protection in low-income settings.Mucosal immunology · 2015Review
- Human milk contains novel glycans that are potential decoy receptors for neonatal rotaviruses.Molecular & cellular proteomics : MCP · 2014Article
- Absence of genetic differences among G10P[11] rotaviruses associated with asymptomatic and symptomatic neonatal infections in Vellore, India.Journal of virology · 2014Article
- Rotavirus shedding in symptomatic and asymptomatic children using reverse transcription-quantitative PCR.Journal of medical virology · 2013Article
- The VP8* domain of neonatal rotavirus strain G10P[11] binds to type II precursor glycans.Journal of virology · 2013Article
- A time-resolved immunoassay to measure serum antibodies to the rotavirus VP6 capsid protein.Journal of virological methods · 2013Article
- Protective effect of natural rotavirus infection in an Indian birth cohort.The New England journal of medicine · 2011Article
- Serum IgG response to Cryptosporidium immunodominant antigen gp15 and polymorphic antigen gp40 in children with cryptosporidiosis in South India.Clinical and vaccine immunology : CVI · 2011Article
- Chronic growth faltering amongst a birth cohort of Indian children begins prior to weaning and is highly prevalent at three years of age.Nutrition journal · 2009Article
- Investigation of a hepatitis A outbreak in children in an urban slum in Vellore, Tamil Nadu, using geographic information systems.The Indian journal of medical research · 2008Article
- Estimates of the economic burden of rotavirus-associated and all-cause diarrhoea in Vellore, India.Tropical medicine & international health : TM & IH · 2008Article
- Why does the world need another rotavirus vaccine?Therapeutics and clinical risk management · 2008Article
- Rotavirus vaccines: an overview.Clinical microbiology reviews · 2008Review
- Molecular characterization of G11P[25] and G3P[3] human rotavirus strains associated with asymptomatic infection in South India.Journal of medical virology · 2007Article
- Rotavirus vaccines: recent developments and future considerations.Nature reviews. Microbiology · 2007Review
Corrections and comments
- Commented on by
Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundVarious observational studies have suggested that neonatal rotavirus infection confers protection against diarrhea due to subsequent rotavirus infection. We examined the incidence of rotavirus infection and diarrhea during the first 2 years of life among children infected with the G10P[11] rotavirus strain during the neonatal period and those not infected with rotavirus.
methodsChildren were recruited at birth and were followed up at least twice weekly. Stool samples, collected every 2 weeks for surveillance and at each episode of diarrhea, were screened by enzyme-linked immunosorbent assay and were genotyped by polymerase chain reaction.
resultsAmong 33 children infected neonatally with G10P[11] and 300 children not infected with rotavirus, there was no significant difference in the rates of rotavirus-positive diarrhea (rate ratio [RR], 1.05 [95% confidence interval [CI], 0.61-1.79]), moderate or severe rotavirus-positive diarrhea (RR, 1.42 [95% CI, 0.73-2.78]), or asymptomatic rotavirus shedding (RR, 1.25 [95% CI, 0.85-1.83]).
conclusionNeonatal G10P[11] infection with a strain resembling a vaccine candidate did not confer protection against subsequent rotavirus infection or diarrhea of any severity in this setting.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.