ReviewMedical & biological engineering & computing2007
Application of mesenchymal stem cell-derived cardiomyocytes as bio-pacemakers: current status and problems to be solved.
Review in Medical & biological engineering & computing, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Acellular Myocardial Scaffolds and Slices Fabrication, and Method for Applying Mechanical and Electrical Simulation to Tissue Construct.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Review
- Mesenchymal stem or stromal cells: a review of clinical applications and manufacturing practices.Transfusion · 2014Review
- Cardiac biomarkers: a focus on cardiac regeneration.The journal of Tehran Heart Center · 2011Article
- Stem cell treatment for patients with autoimmune disease by systemic infusion of culture-expanded autologous adipose tissue derived mesenchymal stem cells.Journal of translational medicine · 2011Article
- Optimizing PANi doped electroactive substrates as patches for the regeneration of cardiac muscle.Journal of materials science. Materials in medicine · 2011Article
- Fabrication of cardiac patch with decellularized porcine myocardial scaffold and bone marrow mononuclear cells.Journal of biomedical materials research. Part A · 2010Article
- Intra-myocardial delivery of mesenchymal stem cells ameliorates left ventricular and cardiomyocyte contractile dysfunction following myocardial infarction.Toxicology letters · 2010Article
- Lin-c-kit(+) BM-derived stem cells repair Infarcted Heart.Journal of stem cells & regenerative medicine · 2010Article
- Myocardial oxygenation and functional recovery in infarct rat hearts transplanted with mesenchymal stem cells.American journal of physiology. Heart and circulatory physiology · 2009Article
- Pre-transplantation specification of stem cells to cardiac lineage for regeneration of cardiac tissue.Stem cell reviews and reports · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone marrow mesenchymal stem cells (CMG cells) are multipotent and can be induced by 5-azacytidine to differentiate into cardiomyocytes. We characterized the electrophysiological properties of these cardiomyocytes and investigated their potential for use as transplantable bio-pacemakers. After differentiation, action potentials in spontaneously beating cardiomyocytes were initially sinus node-like, but subsequently became ventricular cardiomyocyte-like. RT-PCR established that ion channels mediating I(K1) and I(Kr) were expressed before differentiation. After differentiation, ion channels underlying ICa,L and If were expressed first, followed by ion channels mediating I(to) and I(K,ATP). Differentiated CMG cells expressed beta-adrenergic receptors and increased their beat rate in response to isoproterenol. CMG cardiomyocytes were purified using GFP fluorescence and transplanted into the free walls of the left ventricles of mice. The transplanted cardiomyocytes survived and connected to surrounding recipient cardiomyocytes via intercalated discs. Although further innovation is required, the present findings provide evidence of the potential for bone marrow-derived cardiomyocytes to be used as bio-pacemakers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.