ArticleInternational journal of colorectal disease2007
Long-term follow-up after combined fissurectomy and Botox injection for chronic anal fissures.
Article in International journal of colorectal disease, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 60 citations in OpenAlex.
- Gastrointestinal Uses of Botulinum Toxin.Handbook of experimental pharmacology · 2021Trial
- Fissurectomy combined with anoplasty and injection of botulinum toxin in treatment of anterior chronic anal fissure with hypertonia of internal anal sphincter: a pilot study.Techniques in coloproctology · 2010Trial
- Medical and surgical treatment of chronic anal fissure: a prospective study.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2007Trial
- Botulinum toxin associated with fissurectomy and anoplasty for hypertonic chronic anal fissure: A case-control study.World journal of clinical cases · 2021Article
- Fisurectomy and anoplasty with botulinum toxin injection in patients with chronic anal posterior fissure with hypertonia: a long-term evaluation.Updates in surgery · 2021Article
- High-dose versus low-dose botulinum toxin in anal fissure disease.Techniques in coloproctology · 2017Article
- Long-term outcomes of Botulinum toxin in the treatment of chronic anal fissure: 5 years of follow-up.United European gastroenterology journal · 2017Article
- Review
- Combined approach in the treatment of chronic anal fissures.Updates in surgery · 2015Article
- Sphincter-Preserving Therapy for Treating a Chronic Anal Fissure: Long-term Outcomes.Annals of coloproctology · 2014Article
- Advancement flap in the management of chronic anal fissure: a prospective study.Updates in surgery · 2012Article
- Kinetic and reaction pathway analysis in the application of botulinum toxin a for wound healing.Journal of toxicology · 2012Article
- Conservative and surgical treatment of chronic anal fissure: prospective longer term results.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2010Article
- Simple cutaneous advancement flap anoplasty for resistant chronic anal fissure: a prospective study.World journal of surgery · 2009Article
- A pilot comparative study of fissurectomy/diltiazem and fissurectomy/botulinum toxin in the treatment of chronic anal fissure.Techniques in coloproctology · 2008Article
- Continence disorders after anal surgery--a relevant problem?International journal of colorectal disease · 2008Review
- Pharmacological sphincterotomy for chronic anal fissures by botulinum toxin a.Journal of cutaneous and aesthetic surgery · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsChronic anal fissures are difficult to treat. The aim of this retrospective study was to determine the outcome of combined fissurectomy and injection of botulinum toxin Type A (BT). MATERIALS AND
methodsBetween January 2001 and August 2004, 40 patients (21 women), median age 37 years (range 18 to 57), underwent fissurectomy and BT injection. Fissurectomy was performed followed by injection of 10 U of BT into the internal anal sphincter on both sides of the fissure. All patients were clinically checked 6 weeks after the operation. At 1 year, patients were sent a detailed questionnaire regarding symptoms, recurrence and further treatment for evaluation of long-term results. RESULTS/
findingsAt 6 weeks, 38 patients (95%) were free of symptoms. No adverse effects were detected. The response rate of questionnaires was 93%; the median follow-up was 1 year (range 0.9 to 1.6). In the long-term, a recurrence was found in four patients. These patients were treated successfully with repeated fissurectomy and BT injections and salvage procedures, respectively. Overall, the success rate of combined fissurectomy and BT injection was 79%. INTERPRETATION/
conclusionCombined fissurectomy and Botox injection for chronic anal fissure is an excellent and safe procedure with low morbidity and a high healing rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.