ReviewNaunyn-Schmiedeberg's archives of pharmacology2007
Genetics of arterial hypertension and hypotension.
Review in Naunyn-Schmiedeberg's archives of pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Association of G-protein β3 subunit C825T polymorphism with essential hypertension: evidence from 63 729 subjects.Journal of human hypertension · 2017Pooled it
- Role of environmental toxicants in the development of hypertensive and cardiovascular diseases.Toxicology reports · 2022Review
- Sex differences in the blood antioxidant defense system in juvenile rats with various genetic predispositions to hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
- Common variants of the G protein-coupled receptor type 4 are associated with human essential hypertension and predict the blood pressure response to angiotensin receptor blockade.The pharmacogenomics journal · 2016Article
- Network-based analysis of the sphingolipid metabolism in hypertension.Frontiers in genetics · 2015Article
- Construction and analysis of the protein-protein interaction network related to essential hypertension.BMC systems biology · 2013Article
- Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice.The Journal of biological chemistry · 2013Article
- Genetics of the ceramide/sphingosine-1-phosphate rheostat in blood pressure regulation and hypertension.BMC genetics · 2011Article
- Anacardium occidentale Linn. (Anacardiaceae) stem bark extract induces hypotensive and cardio-inhibitory effects in experimental animal models.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2011Article
- β-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein β-3 subunit variant.Pharmacogenomics · 2010Article
- Are "functionally related polymorphisms" of renin-angiotensin-aldosterone system gene polymorphisms associated with hypertension?BMC cardiovascular disorders · 2010Article
- Rgs5 targeting leads to chronic low blood pressure and a lean body habitus.Molecular and cellular biology · 2008Article
- Pharmacogenomics and migraine: possible implications.The journal of headache and pain · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human hypertension affects affects more than 20% of the adult population in industrialized countries, and it is implicated in millions of deaths worldwide each year from stroke, heart failure and ischemic heart disease. Available evidence suggests a major genetic impact on blood pressure regulation. Studies in monogenic hypertension revealed that renal salt and volume regulation systems are predominantly involved in the genesis of these disorders. Mutations here affect the synthesis of mineralocorticoids, the function of the mineralocorticoid receptor, epithelial sodium channels and their regulation by a new class of kinases, termed WNK kinases. It has been learned from monogenic hypotension that almost all ion transporters involved in the renal uptake of Na(+) have a major impact on blood pressure regulation. For essential hypertension as a complex disease, many candidate genes have been analysed. These include components of the renin-angiotensin-aldosterone system, adducin, beta-adrenoceptors, G protein subunits, regulators of G protein signalling (RGS) proteins, Rho kinases and G protein receptor kinases. At present, the individual impact of common polymorphisms in these genes on the observed blood pressure variation, on risk for stroke and as predictors of antihypertensive responses remains small and clinically irrelevant. Nevertheless, these studies have greatly augmented our knowledge on the regulation of renal functions, cellular signal transduction and the integration of both. Together, this provides the basis for the identification of novel drug targets and, hopefully, innovative antihypertensive drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.