ArticleBritish journal of pharmacology2007
Evidence for the expression of multiple uracil nucleotide-stimulated P2 receptors coupled to smooth muscle contraction in porcine isolated arteries.
Article in British journal of pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Involvement of purinergic signalling in the vasomotor response to hypochlorous acid in porcine coronary artery.Purinergic signalling · 2025Article
- Purinergic signalling in the cardiovascular system-a tribute to Geoffrey Burnstock.Purinergic signalling · 2021Article
- On inotropic effects of UTP in the human heart.Heliyon · 2019Review
- UDP-sugars activate P2YVascular pharmacology · 2018Article
- Uridine Adenosine Tetraphosphate-Induced Coronary Relaxation Is Blunted in Swine With Pressure Overload: A Role for Vasoconstrictor Prostanoids.Frontiers in pharmacology · 2018Article
- Mechanisms underlying uridine adenosine tetraphosphate-induced vascular contraction in mouse aorta: Role of thromboxane and purinergic receptors.Vascular pharmacology · 2015Article
- Cardiac purinergic signalling in health and disease.Purinergic signalling · 2015Review
- Effects of NAD at purine receptors in isolated blood vessels.Purinergic signalling · 2015Article
- P2Y₂ receptor activation decreases blood pressure via intermediate conductance potassium channels and connexin 37.Acta physiologica (Oxford, England) · 2015Article
- Novel vasocontractile role of the P2Y₁₄ receptor: characterization of its signalling in porcine isolated pancreatic arteries.British journal of pharmacology · 2014Article
- Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y(6) activation of the phospholipase C/inositol trisphosphate pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- P2Y₂ receptor activation decreases blood pressure and increases renal Na⁺ excretion.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Differential effects of uridine adenosine tetraphosphate on purinoceptors in the rat isolated perfused kidney.British journal of pharmacology · 2010Article
- Myogenic tone in mouse mesenteric arteries: evidence for P2Y receptor-mediated, Na(+), K (+), 2Cl (-) cotransport-dependent signaling.Purinergic signalling · 2009Article
- ATP induces guinea pig gallbladder smooth muscle excitability via the P2Y4 receptor and COX-1 activity.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe uracil nucleotides UDP and UTP have been reported to activate P2Y2, P2Y4 and P2Y6 receptors to cause vasoconstriction. We have performed a comparative analysis of these receptors in endothelium-denuded smooth muscle from porcine isolated coronary and ear arteries, using pharmacological and molecular tools. EXPERIMENTAL APPROACH: Tissue segments were used to construct non-cumulative concentration response curves for UTP and UDP, in the absence and presence of the P2 receptor antagonists PPADS or suramin. RT-PCR and immunoblot analyses were employed to define gene expression and immunoreactivity for P2Y2, P2Y4 and P2Y6 receptors. KEY
resultsIn the coronary artery, UTP-evoked contractile responses were reduced in the presence of suramin, but not PPADS, while the smaller responses to UDP were unaffected by either antagonist. In the ear artery, contractile responses to UDP were much smaller than those to UTP; responses to UTP were inhibited by both PPADS and suramin. RT-PCR suggested predominant expression of P2Y2 receptors in the coronary artery, while P2Y4 and P2Y6 receptor gene expression appeared equivalent in both tissues. Immunoblot analyses provided evidence for P2Y6 receptors in both tissues, with equivocal evidence of P2Y2 and P2Y4 receptor immunoreactivities. CONCLUSIONS AND IMPLICATIONS: We conclude that UTP-evoked contraction of porcine coronary artery smooth muscle appears to be predominantly P2Y2-mediated, while the ear artery appears to express a uracil nucleotide-sensitive P2 receptor(s) which fails to fit readily into the current classification.
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