ArticleProceedings of the National Academy of Sciences of the United States of America2007
A plant porphyria related to defects in plastid import of protochlorophyllide oxidoreductase A.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 40 citations in OpenAlex.
- PRAT Proteins Operate in Organellar Protein Import and Export inPlants (Basel, Switzerland) · 2021Article
- A point mutation in the photosystem I P700 chlorophyll a apoprotein A1 gene confers variegation in Helianthus annuus L.Plant molecular biology · 2020Article
- A Protochlorophyllide (Pchlide)Frontiers in plant science · 2019Article
- Possible import routes of proteins into the cyanobacterial endosymbionts/plastids of Paulinella chromatophora.Theory in biosciences = Theorie in den Biowissenschaften · 2012Article
- The plastid outer envelope protein OEP16 affects metabolic fluxes during ABA-controlled seed development and germination.Journal of experimental botany · 2012Article
- Overexpression of protochlorophyllide oxidoreductase C regulates oxidative stress in Arabidopsis.PloS one · 2011Article
- Tetrapyrrole Metabolism in Arabidopsis thaliana.The arabidopsis book · 2011Article
- Etioplast and etio-chloroplast formation under natural conditions: the dark side of chlorophyll biosynthesis in angiosperms.Photosynthesis research · 2010Review
- AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins.Molecular & cellular proteomics : MCP · 2010Article
- Arabidopsis protochlorophyllide oxidoreductase A (PORA) restores bulk chlorophyll synthesis and normal development to a porB porC double mutant.Plant molecular biology · 2010Article
- Parallel pigment and transcriptomic analysis of four barley albina and xantha mutants reveals the complex network of the chloroplast-dependent metabolism.Plant molecular biology · 2009Article
- A search for factors influencing etioplast-chloroplast transition.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Recent overview of the Mg branch of the tetrapyrrole biosynthesis leading to chlorophylls.Photosynthesis research · 2008Review
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plastid envelope of higher plant chloroplasts is a focal point of plant metabolism. It is involved in numerous pathways, including tetrapyrrole biosynthesis and protein translocation. Chloroplasts need to import a large number of proteins from the cytosol because most are encoded in the nucleus. Here we report that a loss-of-function mutation in the outer plastid envelope 16-kDa protein (oep16) gene causes a conditional seedling lethal phenotype related to defects in import and assembly of NADPH:protochlorophyllide (Pchlide) oxidoreductase A. In the isolated knockout mutant of Arabidopsis thaliana, excess Pchlide accumulated in the dark operated as photosensitizer and provoked cell death during greening. Our results highlight the essential role of the substrate-dependent plastid import pathway of precursor Pchlide oxidoreductase A for seedling survival and the avoidance of developmentally programmed porphyria in higher plants.
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