ArticleMolecular and cellular biology2007
Dss1 interaction with Brh2 as a regulatory mechanism for recombinational repair.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 43 citations in OpenAlex.
- Moss BRCA2 lacking the canonical DNA-binding domain promotes homologous recombination and binds to DNA.Nucleic acids research · 2025Article
- The BRCA2 R2645G variant increases DNA binding and induces hyper-recombination.Nucleic acids research · 2024Article
- Guardians of the Genome: BRCA2 and Its Partners.Genes · 2021Review
- Cancer-causing BRCA2 missense mutations disrupt an intracellular protein assembly mechanism to disable genome maintenance.Nucleic acids research · 2021Article
- The phospho-dependent role of BRCA2 on the maintenance of chromosome integrity.Cell cycle (Georgetown, Tex.) · 2021Review
- DSS1 and ssDNA regulate oligomerization of BRCA2.Nucleic acids research · 2020Article
- Loss of Cohesin Subunit Rec8 Switches Rad51 Mediator Dependence in Resistance to Formaldehyde Toxicity inGenetics · 2018Article
- Dss1 Regulates Association of Brh2 with Rad51.Biochemistry · 2017Article
- Molding BRCA2 function through its interacting partners.Cell cycle (Georgetown, Tex.) · 2015Review
- Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor.Nature structural & molecular biology · 2014Article
- Dual DNA-binding domains shape the interaction of Brh2 with DNA.DNA repair · 2014Article
- Review
- DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells.Protein & cell · 2014Article
- BRCA2: one small step for DNA repair, one giant protein purified.The Yale journal of biology and medicine · 2013Review
- A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization.Nature structural & molecular biology · 2013Article
- Brh2 and Rad51 promote telomere maintenance in Ustilago maydis, a new model system of DNA repair proteins at telomeres.DNA repair · 2013Article
- Trypanosoma brucei BRCA2 acts in a life cycle-specific genome stability process and dictates BRC repeat number-dependent RAD51 subnuclear dynamics.Nucleic acids research · 2013Article
- Dss1 release activates DNA binding potential in Brh2.Biochemistry · 2012Article
- Homologous recombination and its regulation.Nucleic acids research · 2012Review
- Brh2 domain function distinguished by differential cellular responses to DNA damage and replication stress.Molecular microbiology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brh2, the BRCA2 ortholog in Ustilago maydis, enables recombinational repair of DNA by controlling Rad51 and is in turn regulated by Dss1. Interplay with Rad51 is conducted via the BRC element located in the N-terminal region of the protein and through an unrelated domain, CRE, at the C terminus. Mutation in either BRC or CRE severely reduces functional activity, but repair deficiency of the brh2 mutant can be complemented by expressing BRC and CRE on different molecules. This intermolecular complementation is dependent upon the presence of Dss1. Brh2 molecules associate through the region overlapping with the Dss1-interacting domain to form at least dimer-sized complexes, which in turn, can be dissociated by Dss1 to monomer. We propose that cooperation between BRC and CRE domains and the Dss1-provoked dissociation of Brh2 complexes are requisite features of Brh2's molecular mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.