ArticleTheoretical biology & medical modelling2007
A computational model for functional mapping of genes that regulate intra-cellular circadian rhythms.
Article in Theoretical biology & medical modelling, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Dynamic modeling of genes controlling cancer stem cell proliferation.Frontiers in genetics · 2012Article
- A dynamic model for functional mapping of biological rhythms.Journal of biological dynamics · 2011Article
- Chronopharmaceutical drug delivery systems: Hurdles, hype or hope?Advanced drug delivery reviews · 2010Review
- Nonparametric modeling of longitudinal covariance structure in functional mapping of quantitative trait loci.Biometrics · 2009Article
- A statistical model for the identification of genes governing the incidence of cancer with age.Theoretical biology & medical modelling · 2008Article
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Authors and funding
4 authors.
Funding
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Abstract
backgroundGenes that control circadian rhythms in organisms have been recognized, but have been difficult to detect because circadian behavior comprises periodically dynamic traits and is sensitive to environmental changes.
methodWe present a statistical model for mapping and characterizing specific genes or quantitative trait loci (QTL) that affect variations in rhythmic responses. This model integrates a system of differential equations into the framework for functional mapping, allowing hypotheses about the interplay between genetic actions and periodic rhythms to be tested. A simulation approach based on sustained circadian oscillations of the clock proteins and their mRNAs has been designed to test the statistical properties of the model.
conclusionThe model has significant implications for probing the molecular genetic mechanism of rhythmic oscillations through the detection of the clock QTL throughout the genome.
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