ArticleInternational journal of colorectal disease2007
Risk factors for clinical anastomotic leakage and postoperative mortality in elective surgery for rectal cancer.
Article in International journal of colorectal disease, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 53 papers, 6 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Quantitative Fluorescent Guided Robotic Surgery for Cancer of the Gastroesophageal Junction
The Effect of Chemoradiotherapy on Gastric Perfusion in Patients With Gastric Cancer.
Who cites it
53 citing papers in PubMed, 6 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Preoperative risk factors associated with anastomotic leakage after colectomy for colorectal cancer: a systematic review and meta-analysis.Revista do Colegio Brasileiro de Cirurgioes · 2022Pooled it
- Prediction of anastomotic leak in colorectal cancer surgery based on a new prognostic index PROCOLE (prognostic colorectal leakage) developed from the meta-analysis of observational studies of risk factors.International journal of colorectal disease · 2016Pooled it
- Alcohol drinking does not affect postoperative surgical site infection or anastomotic leakage: a systematic review and meta-analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2014Pooled it
- Systematic review on the value of CT scanning in the diagnosis of anastomotic leakage after colorectal surgery.International journal of colorectal disease · 2013Pooled it
- Pooled it
- Incidence and mortality of anastomotic dehiscence requiring reoperation after rectal carcinoma resection.International surgeryPooled it
- Calcification of the iliac arteries: a marker for leakage risk in rectal anastomosis-a blinded clinical trial.International journal of colorectal disease · 2018Trial
- Protection of intestinal anastomosis with biological glues: an experimental randomized controlled trial.Techniques in coloproctology · 2011Trial
- ETVARD (endoscopic transanal vacuum-assisted rectal drainage) leads to complete but delayed closure of extraperitoneal rectal anastomotic leakage cavities following neoadjuvant radiochemotherapy.International journal of colorectal disease · 2009Trial
- Article
- Article
- Implementation of intraoperative procedures to prevent anastomotic leak in low anterior rectal resections: a pilot study for a novel technique to evaluate anastomotic vascularization.Surgical endoscopy · 2025Article
- Machine learning-based preoperative analytics for the prediction of anastomotic leakage in colorectal surgery: a swiss pilot study.Surgical endoscopy · 2024Article
- A comparative study of stoma-related complications from diverting loop ileostomy or colostomy after colorectal surgery.Langenbeck's archives of surgery · 2023Article
- A nationwide population-based study on the clinical and economic burden of anastomotic leakage in colorectal surgery.Langenbeck's archives of surgery · 2023Article
- Smoking cessation for less than 10 years remains a risk factor of anastomotic leakage in mid-to-low rectal cancer patients undergoing sphincter-preserving surgery.Langenbeck's archives of surgery · 2022Article
- Mesenteric occlusive disease of the inferior mesenteric artery is associated with anastomotic leak after left-sided colon and rectal cancer surgery: a retrospective cohort study.International journal of colorectal disease · 2022Article
- Efficacy of side-to-end anastomosis to prevent anastomotic leakage after anterior resection for rectal cancer.Molecular and clinical oncology · 2022Article
- Quantitative fluorescence angiography detects dynamic changes in gastric perfusion.Surgical endoscopy · 2021Article
- The assessment of perioperative risk factors of anastomotic leakage after intestinal surgeries; a prospective study.BMC surgery · 2021Observational
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsClinical anastomotic leakage remains a major problem after anterior or low anterior resection for rectal cancer. The aim of this study was to assess the association between risk factors and anastomotic leakage and postoperative mortality. MATERIALS AND
methodsTwo hundred seventy-six elective anterior or low anterior resections with anastomosis were performed and documented on-line from January 1995 to December 2004. Univariate and multivariate analyses with Bonferroni adjustment were carried out to identify relevant risk factors.
resultsThe rate of anastomotic leakage was 14.9% (41 of 276 patients) with a mortality of 12.2% (5 of 41 patients). Overall mortality was 2.5% (7 of 276 patients). Multiple regression analysis showed that smokers had an increased risk of anastomotic leakage [odds ratio (OR), 6.42; 95% confidence interval (CI), 2.68-15.36] as well as patients with coronary heart disease (OR, 7.79; 95% CI, 2.52-24.08). Smokers (OR, 13.20; 95% CI, 2.48-7.24) and patients with coronary heart disease (OR, 23.46; 95% CI, 4.33-27.04) also had an increased risk of postoperative mortality in the univariate analysis as well as patients with anastomotic leakage (OR, 16.25; 95% CI, 3.04-16.92).
conclusionsSmoking and coronary heart disease are important risk factors for anastomotic leakage and postoperative mortality after elective resection for rectal cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.