ArticleClinical & experimental metastasis2007
Major but not minor hepatectomy accelerates engraftment of extrahepatic tumor cells.
Article in Clinical & experimental metastasis, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- The role of ischaemia-reperfusion injury and liver regeneration in hepatic tumour recurrence.JHEP reports : innovation in hepatology · 2023Review
- Long-term oncological outcomes after laparoscopic parenchyma-sparing redo liver resections for patients with metastatic colorectal cancer: a European multi-center study.Surgical endoscopy · 2022Article
- Simultaneous curative resection of double colorectal carcinoma with synchronous bilobar liver metastases.World journal of gastrointestinal oncology · 2018Review
- Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice.Journal of visualized experiments : JoVE · 2018Article
- Parenchymal-sparing liver surgery in patients with colorectal carcinoma liver metastases.World journal of gastrointestinal surgery · 2016Review
- Hepatocellular carcinoma: Surgeon's view on latest findings and future perspectives.World journal of hepatology · 2015Review
- Targeting of circulating hepatocellular carcinoma cells to prevent postoperative recurrence and metastasis.World journal of gastroenterology · 2014Review
- Tumour growth stimulation following partial hepatectomy in mice is associated with increased upregulation of c-Met.Clinical & experimental metastasis · 2014Article
- Parenchyma-preserving hepatic resection for colorectal liver metastases.Langenbeck's archives of surgery · 2012Article
- Bone Marrow Suppression by c-Kit Blockade Enhances Tumor Growth of Colorectal Metastases through the Action of Stromal Cell-Derived Factor-1.Journal of oncology · 2012Article
- Risk factors for residual tumor after resection of hepatocellular carcinoma.World journal of gastroenterology · 2011Article
- Accomplishments in 2007 in the management of curable metastatic colorectal cancer.Gastrointestinal cancer research : GCR · 2008Article
- Stromal cell-derived factor-1 promotes cell migration and tumor growth of colorectal metastasis.Neoplasia (New York, N.Y.) · 2007Article
- Hepatic Metastasis from Colorectal Cancer.Euroasian journal of hepato-gastroenterologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effect of hepatectomy and hepatic regeneration on intra- and extrahepatic tumor growth is still controversially discussed. Herein we studied the effect of minor (30%) or major (70%) hepatectomy on engraftment of extrahepatic tumor cells, and the role of tumor neovascularization and tumor cell migration.
methodsGreen fluorescent protein (GFP)-transfected CT26.WT colorectal cancer cells were implanted in dorsal skinfold chambers of syngeneic BALB/c mice. Animals underwent 30% (30%Phx, n = 8) or 70% hepatectomy (70%Phx, n = 8). Sham-operated animals served as controls (n = 8). Angiogenesis and neovascularization as well as tumor cell migration, proliferation and growth were studied over 14 days using intravital fluorescence microscopy, histology and immunohistochemistry.
resultsAfter both minor and major hepatectomy tumor proliferating cell nuclear antigen (PCNA) expression increased significantly (P < 0.05) when compared with nonhepatectomized controls. However, only major but not minor hepatectomy accelerated neovascularization (P < 0.05) and tumor cell migration (P < 0.05). This was associated with a significantly (P < 0.05) enhanced tumor growth after 70%Phx when compared with 30%Phx and controls. The rate of apoptotic cell death was not affected by major or minor hepatectomy.
conclusionRegeneration after major hepatectomy accelerates extrahepatic tumor cell engraftment, most probably by acceleration of neovascularization and induction of tumor cell migration.
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