ArticleBreast cancer research and treatment2007
Differential effects of tamoxifen and anastrozole on optic cup size in breast cancer survivors.
Article in Breast cancer research and treatment, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Prevalence of symptomatic dry eye in breast cancer patients undergoing systemic adjuvant treatment: A cross-sectional study.Breast (Edinburgh, Scotland) · 2020Article
- The effects of adjuvant hormonotherapy on tear functions in patients with breast cancer.International ophthalmology · 2020Article
- Bilateral Optic Disc Swelling Following Anastrozole Therapy.Neuro-ophthalmology (Aeolus Press) · 2014Article
- Ocular side effects of biological agents in oncology: what should the clinician be aware of?OncoTargets and therapy · 2013Review
- Breast cancer medications and vision: effects of treatments for early-stage disease.Current eye research · 2011Review
- Variability in short-wavelength automated perimetry among peri- or postmenopausal women: a dependence on phyto-oestrogen consumption?Acta ophthalmologica · 2011Article
- Identifying factors associated with falls in postmenopausal breast cancer survivors: a multi-disciplinary approach.Archives of physical medicine and rehabilitation · 2011Article
- A review of exercise interventions to improve bone health in adult cancer survivors.Journal of cancer survivorship : research and practice · 2010Review
- Vitreo-retinal traction and anastrozole use.Breast cancer research and treatment · 2009Article
- The color appearance of stimuli detected via short-wavelength-sensitive cones: comparisons with visual adaptation and visual field data for peri- or post-menopausal women under 70 years of age.Vision research · 2008Article
- Article
- Ocular Side Effects of Aromatase Inhibitor Endocrine Therapy in Breast Cancer - A Review.In vivo (Athens, Greece)Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
introductionThe main purpose of this study was to determine whether the optic cups of tamoxifen users and anastrozole users differ in size, with the cups of the tamoxifen users being smaller.
methodsOptic nerve head (ONH) topography was measured using a commercially available, confocal scanning laser ophthalmoscope for three populations of amenorrheic women ages 40-69 years: subjects using (1) tamoxifen (20 mg/day) or (2) anastrozole (1 mg/day) for < or = 2 years as adjuvant therapy after successful primary treatment for breast cancer, and (3) control subjects with no breast cancer histories and not using any hormonal medication. All subjects had excellent visual acuity and healthy eyes, based on conventional photographic assessment.
resultsThe cup volumes of the tamoxifen users were shown to be significantly smaller than the cup volumes of the anastrozole users, which were indistinguishable from normal. Because the cup volumes of the tamoxifen users decreased markedly with age at about 50 years and because anastrozole is indicated only for post-menopausal women, comparisons were reassessed for subjects older than 50 years. For these subjects, the cup volumes of the tamoxifen users averaged less than half of the volumes for each of the other two subject groups, and significant between-group differences existed in both the lateral (cup area) and axial (cup depth) directions. In contrast, any between-group differences at the ONH margin were small and not significant.
conclusionsThe results of this study suggest that the ONH be assessed biomorphometrically for tamoxifen users reporting visual change that cannot be attributed to non-tamoxifen causes. The ability of modern intraocular imaging techniques to reveal anatomic change on the order of tens of microns may be useful for assessing tamoxifen-induced effects occurring simultaneously elsewhere in the brain, particularly since the presence of small cups is consistent with the possibility of tamoxifen-induced astrocytic swelling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.