ArticleOncogene2007
Global DNA methylation profiling reveals silencing of a secreted form of Epha7 in mouse and human germinal center B-cell lymphomas.
Article in Oncogene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- DNA methylation of hematopoietic stem/progenitor cells from donor peripheral blood to patient bone marrow: implications for allogeneic hematopoietic stem cell transplantation.Clinical and experimental medicine · 2023Article
- Review
- The role of EphA7 in different tumors.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022Review
- Identification of the soluble EphA7-interacting protein Nicalin as a regulator of EphA7 expression.Molecular and cellular biochemistry · 2021Article
- Receptor Tyrosine Kinase EphB3: a Prognostic Indicator in Colorectal Carcinoma.Pathology oncology research : POR · 2020Article
- Differential expression of EphA5 protein in gastric carcinoma and its clinical significance.Oncology letters · 2019Article
- Association of Genetic Variants With Warfarin-Associated Bleeding Among Patients of African Descent.JAMA · 2018Article
- Erythropoietin-producing hepatocellular A7 triggering ovulation indicates a potential beneficial role for polycystic ovary syndrome.EBioMedicine · 2018Article
- The putative tumor suppressor gene EphA7 is a novel BMI-1 target.Oncotarget · 2016Article
- Secreted Ephrin Receptor A7 Promotes Somatic Cell Reprogramming by Inducing ERK Activity Reduction.Stem cell reports · 2015Article
- Therapeutic targeting of EPH receptors and their ligands.Nature reviews. Drug discovery · 2014Review
- Functional genomics lead to new therapies in follicular lymphoma.Annals of the New York Academy of Sciences · 2013Review
- Pathogenesis of follicular lymphoma.The Journal of clinical investigation · 2012Review
- Mining the cancer genome uncovers therapeutic activity of EphA7 against lymphoma.Cell cycle (Georgetown, Tex.) · 2012Article
- Article
- Rapid, massively parallel single-cell drug response measurements via live cell interferometry.Biophysical journal · 2011Article
- Article
- EPH-EPHRIN in human gastrointestinal cancers.World journal of gastrointestinal oncology · 2010Article
- Eph receptors and ephrins in cancer: bidirectional signalling and beyond.Nature reviews. Cancer · 2010Review
- Epigenetic silencing of Stk39 in B-cell lymphoma inhibits apoptosis from genotoxic stress.The American journal of pathology · 2009Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
Most human lymphomas originate from transformed germinal center (GC) B lymphocytes. While activating mutations and translocations of MYC, BCL2 and BCL6 promote specific GC lymphoma subtypes, other genetic and epigenetic modifications that contribute to malignant progression in the GC remain poorly defined. Recently, aberrant expression of the TCL1 proto-oncogene was identified in major GC lymphoma subtypes. TCL1 transgenic mice offer unique models of both aggressive GC and marginal zone B-cell lymphomas, further supporting a role for TCL1 in B-cell transformation. Here, restriction landmark genomic scanning was employed to discover tumor-associated epigenetic alterations in malignant GC and marginal zone B-cells in TCL1 transgenic mice. Multiple genes were identified that underwent DNA hypermethylation and decreased expression in TCL1 transgenic tumors. Further, we identified a secreted isoform of EPHA7, a member of the Eph family of receptor tyrosine kinases that are able to influence tumor invasiveness, metastasis and neovascularization. EPHA7 was hypermethylated and repressed in both mouse and human GC B-cell non-Hodgkin lymphomas, with the potential to influence tumor progression and spread. These data provide the first set of hypermethylated genes with the potential to complement TCL1-mediated GC B-cell transformation and spread.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.