ArticleBiophysical journal2007
Mechanism of tension generation in muscle: an analysis of the forward and reverse rate constants.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Temperature dependence of activation of thick and thin filaments in skeletal and cardiac muscles.Journal of muscle research and cell motility · 2026Review
- Effects of Hydrostatic-Pressure on Muscle Contraction: A Look Back on Some Experimental Findings.International journal of molecular sciences · 2023Review
- Temperature Effects on Force and Actin⁻Myosin Interaction in Muscle: A Look Back on Some Experimental Findings.International journal of molecular sciences · 2018Review
- Phosphate and acidosis act synergistically to depress peak power in rat muscle fibers.American journal of physiology. Cell physiology · 2014Article
- Mechanism of force enhancement during and after lengthening of active muscle: a temperature dependence study.Journal of muscle research and cell motility · 2012Article
- Force and power generating mechanism(s) in active muscle as revealed from temperature perturbation studies.The Journal of physiology · 2010Review
- Temperature change as a probe of muscle crossbridge kinetics: a review and discussion.Proceedings. Biological sciences · 2009Review
- Mechanistic role of movement and strain sensitivity in muscle contraction.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- The cardiac Ca2+-sensitive regulatory switch, a system in dynamic equilibrium.Biophysical journal · 2008Article
- An analysis of the temperature dependence of force, during steady shortening at different velocities, in (mammalian) fast muscle fibres.Journal of muscle research and cell motility · 2008Article
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Authors and funding
2 authors.
Funding
Abstract
Tension generation in muscle occurs during the attached phase of the ATP-powered cyclic interaction of myosin heads with thin filaments. The transient nature of tension-generating intermediates and the complexity of the mechanochemical cross-bridge cycle have impeded a quantitative description of tension generation. Recent experiments performed under special conditions yielded a sigmoidal dependence of fiber tension on temperature--a unique case that simplifies the system to a two-state transition. We have applied this two-state analysis to kinetic data obtained from biexponential laser temperature-jump tension transients. Here we present the forward and reverse rate constants for de novo tension generation derived from analysis of the kinetics of the fast laser temperature-jump phase tau(2) (equivalent of the length-jump phase 2(slow)). The slow phase tau(3) is temperature-independent indicating coupling to rather than a direct role in, de novo tension generation. Increasing temperature accelerates the forward, and slows the reverse, rate constant for the creation of the tension-generating state. Arrhenius behavior of the forward and anti-Arrhenius behavior of the reverse rate constant is a kinetic signature of multistate multipathway protein-folding reactions. We conclude that locally unfolded tertiary and/or secondary structure of the actomyosin cross-bridge mediates the power stroke.
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