ArticleThe Plant cell2007
The acyltransferase GPAT5 is required for the synthesis of suberin in seed coat and root of Arabidopsis.
Article in The Plant cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 200 papers.
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Who cites it
200 citing papers in PubMed, 465 citations in OpenAlex.
- Unexpected Suppression of Tomato Fruit Cuticle Formation by Overexpression of a Key Cutin Biosynthetic Enzyme.Plant biotechnology journal · 2026Article
- Identification and Functional Characterization of the GPAT Gene Family in Regulating Oil Biosynthesis in Olive.Plants (Basel, Switzerland) · 2026Article
- Cracking the Hard Seed: Molecular Mechanisms and Multi-Omics Insights into Seed Dormancy and Germination in the GenusInternational journal of molecular sciences · 2026Review
- Phospholipid Networks as Metabolic Hubs and Signaling Integrators in Plant Development and Stress Adaptation.Plants (Basel, Switzerland) · 2026Review
- GhUGT84A1 underlying a novel locus qOC-A03-1 regulates cottonseed oil content revealed by integrated deep resequencing and QTL mapping.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Genome-wide characterization and transcriptional profiling of the glycerol-3-phosphate acyltransferase (GPAT) family in barley reveals the role of HvGPAT1 in low nitrogen tolerance.BMC plant biology · 2026Article
- Thermal priming enhances heat tolerance in alfalfa (Medicago sativa L.) through activation of multiple metabolic pathways.BMC plant biology · 2025Article
- Clathrin-mediated endocytosis regulates root endodermal suberization via ROS.The New phytologist · 2025Article
- Review
- Mitochondrial GPATs protect Arabidopsis from water stress by impacting cuticle and secondary cell wall development.Plant cell reports · 2025Article
- Enhanced growth and productivity of useful metabolites by indole-3-propionic acid treatment in Lemna aequinoctialis culture.BMC plant biology · 2025Article
- Wounding induces multilayered barrier formation in mature leaves via phytohormone signalling and ATML1-mediated epidermal specification.Nature plants · 2025Article
- A single-nuclei transcriptome census of the Arabidopsis maturing root identifies that MYB67 controls phellem cell maturation.Developmental cell · 2025Article
- Rhizobacteria protective hydrogel to promote plant growth and adaption to acidic soil.Nature communications · 2025Article
- Temperature-dependent polar lignification of a seed coat suberin layer promoting dormancy inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Naturally russeted and wound russeted skins of mango (cv. 'Apple') show no differences in anatomy, chemical composition or gene expression.Scientific reports · 2025Article
- Suberin in plants: biosynthesis, regulation, and its role in salt stress resistance.Frontiers in plant science · 2025Review
- Four MYB transcription factors regulate suberization and nonlocalized lignification at the root endodermis in rice.The Plant cell · 2024Article
- Genome-Wide Identification of the GPAT Family inPlants (Basel, Switzerland) · 2024Article
- Genome-wide association study of cassava brown streak disease resistance in cassava germplasm conserved in South America.Scientific reports · 2024Article
140 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Suberin and cutin are fatty acid- and glycerol-based plant polymers that act as pathogen barriers and function in the control of water and solute transport. However, despite important physiological roles, their biosynthetic pathways, including the acyl transfer reactions, remain hypothetical. We report the characterization of two suberin mutants (gpat5-1 and gpat5-2) of Arabidopsis thaliana GPAT5, encoding a protein with acyl-CoA:glycerol-3-phosphate acyltransferase activity. RT-PCR and beta-glucuronidase-promoter fusion analyses demonstrated GPAT5 expression in seed coat, root, hypocotyl, and anther. The gpat5 plants showed a 50% decrease in aliphatic suberin in young roots and produced seed coats with a severalfold reduction in very long chain dicarboxylic acid and omega-hydroxy fatty acids typical of suberin but no change in the composition or content of membrane or storage glycerolipids or surface waxes. Consistent with their altered suberin, seed coats of gpat5 mutants had a steep increase in permeability to tetrazolium salts compared with wild-type seed coats. Furthermore, the germination rate of gpat5 seeds under high salt was reduced, and gpat5 seedlings had lower tolerance to salt stress. These results provide evidence for a critical role of GPAT5 in polyester biogenesis in seed coats and roots and for the importance of lipid polymer structures in the normal function of these organs.
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