ArticleExperimental hematology2007
Hematopoietic progenitor cells (HPC) from mobilized peripheral blood display enhanced migration and marrow homing compared to steady-state bone marrow HPC.
Article in Experimental hematology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Article
- Current Developments in Mobilization of Hematopoietic Stem and Progenitor Cells and Their Interaction with Niches in Bone Marrow.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2017Review
- Article
- Melittin inhibits tumor angiogenesis modulated by endothelial progenitor cells associated with the SDF-1α/CXCR4 signaling pathway in a UMR-106 osteosarcoma xenograft mouse model.Molecular medicine reports · 2016Article
- Functional consequences of perturbed CXCL12 signal processing: analyses of immature hematopoiesis in GRK6-deficient mice.Stem cells and development · 2015Article
- Cyclin A1 regulates the interactions between mouse haematopoietic stem and progenitor cells and their niches.Cell cycle (Georgetown, Tex.) · 2015Article
- Article
- Effects of storage temperature on hematopoietic stability and microbial safety of BM aspirates.Bone marrow transplantation · 2014Article
- The role of bioactive lipids in stem cell mobilization and homing: novel therapeutics for myocardial ischemia.BioMed research international · 2014Review
- A novel role for bioactive lipids in stem cell mobilization during cardiac ischemia: new paradigms in thrombosis: novel mediators and biomarkers.Journal of thrombosis and thrombolysis · 2014Review
- The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor.Leukemia · 2013Article
- The role of dipeptidyl peptidase 4 in hematopoiesis and transplantation.Current opinion in hematology · 2013Review
- Regulatory systems in bone marrow for hematopoietic stem/progenitor cells mobilization and homing.BioMed research international · 2013Review
- Review
- The ins and outs of hematopoietic stem cells: studies to improve transplantation outcomes.Stem cell reviews and reports · 2011Review
- Spotlight series on stem cell mobilization: many hands on the ball, but who is the quarterback?Leukemia · 2010Article
- Innate immunity as orchestrator of stem cell mobilization.Leukemia · 2010Review
- Insights into the biology of mobilized hematopoietic stem/progenitor cells through innovative treatment schedules of the CXCR4 antagonist AMD3100.Experimental hematology · 2009Article
- Hematopoietic stem and progenitor cells: their mobilization and homing to bone marrow and peripheral tissue.Immunologic research · 2009Review
- Peripheral blood stem cell mobilization: new regimens, new cells, where do we stand.Current opinion in hematology · 2008Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveFaster engraftment of G-CSF-mobilized peripheral blood (MPB) transplants compared to steady-state bone marrow (ssBM) is well documented and clinically relevant. A number of different factors likely contribute to this outcome. In the present study we explored whether independent of cell number there are intrinsic differences in the efficiency of progenitor cell homing to marrow between MPB and ssBM.
methodsMobilization was achieved by continuous infusion of G-CSF alone or in combination with other mobilizing agents. In vivo homing assays, in vitro migration assays, gene expression analysis, and flow cytometry were utilized to compare homing-related in vivo and in vitro properties of MPB and ssBM HPC.
resultsMarrow homing of murine MPB HPC, generated by different mobilizing schemes, was reproducibly significantly superior to that of ssBM, in lethally irradiated as well as in nonirradiated hosts. This phenotype was independent of MMP9, selectins, and beta2- and alpha4-integrins. Superior homing was also observed for human MPB HPC transplanted into NOD/SCIDbeta2microglobulin(-/-) recipients. Inhibition of HPC migration abrogated the homing advantage of MPB but did not affect homing of ssBM HPC, whereas enhancement of motility by CD26 inhibition improved marrow homing only of ssBM HPC. Enhanced SDF-1-dependent chemotaxis and low CD26 expression on MPB HPC were identified as potential contributing factors. Significant contributions of the putative alternative SDF-1 receptor, RDC1, were unlikely based on gene expression data.
conclusionThe data suggest increased motility as a converging endpoint of complex changes seen in MPB HPC which is likely responsible for their favorable homing.
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