ArticleThe Journal of steroid biochemistry and molecular biology2007
New insights into the function and regulation of vitamin D target proteins.
Article in The Journal of steroid biochemistry and molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 34 citations in OpenAlex.
- Nutraceuticals in Pregnancy: A Special Focus on Probiotics.International journal of molecular sciences · 2024Review
- Cytosolic CaCold Spring Harbor perspectives in biology · 2020Review
- Vitamin D Attenuates Oxidative Damage and Inflammation in Retinal Pigment Epithelial Cells.Antioxidants (Basel, Switzerland) · 2019Article
- Brg1 Controls the Expression of Pax7 to Promote Viability and Proliferation of Mouse Primary Myoblasts.Journal of cellular physiology · 2015Article
- Inhibition of West Nile virus by calbindin-D28k.PloS one · 2014Article
- Peripubertal vitamin D(3) deficiency delays puberty and disrupts the estrous cycle in adult female mice.Biology of reproduction · 2012Article
- Vitamin D in the new millennium.Current osteoporosis reports · 2012Review
- The renaissance of Ca2+-binding proteins in the nervous system: secretagogin takes center stage.Cellular signalling · 2012Review
- Cytosolic Ca2+ buffers.Cold Spring Harbor perspectives in biology · 2010Review
- Protein expression in the nucleus accumbens of rats exposed to developmental vitamin D deficiency.PloS one · 2008Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Calbindin-D(28k) has been reported to be a facilitator of calcium diffusion and to protect against apoptotic cell death. Most recently, we found that the presence of calbindin-D(28k) results in reduced calcium influx through voltage-dependent L-type Ca(2+) channels and enhanced sensitivity of the channels to calcium dependent inactivation. Co-immunoprecipitation and GST pull down assays indicate that calbindin-D(28k) interacts with the C-terminus of the L-type calcium channel alpha(1c) subunit (Ca(v)1.2). This is the first report of the binding of calbindin to a calcium channel and provides new insight concerning mechanisms by which calbindin acts to modulate intracellular calcium. Besides calbindin, another major target of 1,25(OH)(2)D(3) is 24(OH)ase, which is involved in the catabolism of 1,25(OH)(2)D(3). We reported that C/EBPbeta is a major transcriptional activator of 24(OH)ase that cooperates with CBP/p300 in regulating VDR mediated 24(OH)ase transcription. Recently, we found, in addition to p160 coactivators, that SWI/SNF complexes (that facilitate transcription by remodeling chromatin using the energy of ATP hydrolysis) are also involved in VDR mediated 24(OH)ase transcription and functionally cooperate with C/EBPbeta in regulating 24(OH)ase. These findings define novel mechanisms that may be of fundamental importance in understanding how 1,25(OH)(2)D(3) mediates its multiple biological effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.