ArticleDevelopmental biology2007
Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 51 citations in OpenAlex.
- Coupled dopamine and insulin signaling mediated transgenerational and multigenerational inheritance of adaptive traits inMicrobiology spectrum · 2025Article
- The neurohormone tyramine stimulates the secretion of an insulin-like peptide from the Caenorhabditis elegans intestine to modulate the systemic stress response.PLoS biology · 2025Article
- A non-canonical role of somatic Cyclin D/CYD-1 in oogenesis and in maintenance of reproductive fidelity, dependent on the FOXO/DAF-16 activation state.PLoS genetics · 2024Article
- Potential Active Marine Peptides as Anti-Aging Drugs or Drug Candidates.Marine drugs · 2023Review
- Endogenous DAF-16 spatiotemporal activity quantitatively predicts lifespan extension induced by dietary restriction.Communications biology · 2023Article
- Microtubule regulators act in the nervous system to modulate fat metabolism and longevity through DAF-16 in C. elegans.Aging cell · 2019Article
- Age-Dependence and Aging-Dependence: Neuronal Loss and Lifespan in a C. elegans Model of Parkinson's Disease.Biology · 2017Article
- Gene-diet interactions and aging in C. elegans.Experimental gerontology · 2016Article
- Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model.Molecular neurodegeneration · 2016Article
- The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster.BMB reports · 2016Review
- Insulin, aging, and the brain: mechanisms and implications.Frontiers in endocrinology · 2015Review
- Insight into insulin secretion from transcriptome and genetic analysis of insulin-producing cells of Drosophila.Genetics · 2014Article
- The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans.Neurotoxicology · 2014Article
- Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators.Cell metabolism · 2013Article
- Neuronal inputs and outputs of aging and longevity.Frontiers in genetics · 2013Article
- Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Article
- Regulation of Caenorhabditis elegans vitellogenesis by DAF-2/IIS through separable transcriptional and posttranscriptional mechanisms.BMC physiology · 2011Article
- Co-regulation of the DAF-16 target gene, cyp-35B1/dod-13, by HSF-1 in C. elegans dauer larvae and daf-2 insulin pathway mutants.PloS one · 2011Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In C. elegans, insulin signaling affects development, lifespan and stress resistance. Several studies have shown that insulin signaling affects lifespan in an endocrine-like manner from different cells, while the major downstream target of insulin, the FOXO transcription factor encoded by daf-16, may act preferentially in intestinal cells to prolong lifespan. This discrepancy raised the possibility that insulin may have both endocrine and cell-intrinsic outputs. Here, we further investigated the types of cells capable of producing endocrine outputs of insulin and also identified a new cell-intrinsic insulin output. We found that insulin signaling within groups of neurons promoted wildtype lifespan, showing that the endocrine outputs of insulin were not restricted to specific cells. In contrast, DAF-16 appeared to have a greater effect on lifespan when expressed in a combination of tissues. These results suggest that insulin signaling may regulate DAF-16 through cell-intrinsic and endocrine pathways. We also found that an insulin-dependent response to fasting in intestinal cells was preferentially regulated by intestinal insulin signaling and was less responsive to insulin signaling from non-intestinal cells. Together, these results show that C. elegans insulin signaling has endocrine as well as tissue-specific outputs which could influence lifespan in a combinatorial fashion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.