ArticleDiabetic medicine : a journal of the British Diabetic Association2007
Pancreatic B-cell function is altered by oxidative stress induced by acute hyperglycaemia.
Article in Diabetic medicine : a journal of the British Diabetic Association, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 62 citations in OpenAlex.
- Postprandial oxidative stress in response to dextrose and lipid meals of differing size.Lipids in health and disease · 2010Trial
- Effects of GI vs content of cereal fibre of the evening meal on glucose tolerance at a subsequent standardized breakfast.European journal of clinical nutrition · 2008Trial
- The interplay of tumor suppressor p53 and oxidative stress in pancreatic β-cell apoptosis and insulin resistance in newly diagnosed type 2 diabetes mellitus.Diabetology & metabolic syndrome · 2025Article
- Effects of Mulberry Leaf Fu Tea on the Intestines and Intestinal Flora of Goto-Kakizaki Type 2 Diabetic Rats.Foods (Basel, Switzerland) · 2023Article
- Acute exercise and high-glucose ingestion elicit dynamic and individualized responses in systemic markers of redox homeostasis.Frontiers in immunology · 2023Article
- Effects of cannabidiol on vacuous chewing movements, plasma glucose and oxidative stress indices in rats administered high dose risperidone.Scientific reports · 2022Article
- Predictors of acarbose therapeutic efficacy in newly diagnosed type 2 diabetes mellitus patients in China.BMC pharmacology & toxicology · 2022Article
- Reactive oxygen species in exercise and insulin resistance: Working towards personalized antioxidant treatment.Redox biology · 2021Review
- Protective Effects of an Oxovanadium(IV) Complex with NBiological trace element research · 2021Article
- A Putative Prohibitin-Calcium Nexus inJournal of diabetes research · 2020Review
- Exercise and Glycemic Control: Focus on Redox Homeostasis and Redox-Sensitive Protein Signaling.Frontiers in endocrinology · 2017Review
- Extracts of black bean peel and pomegranate peel ameliorate oxidative stress-induced hyperglycemia in mice.Experimental and therapeutic medicine · 2015Article
- Decreased thioredoxin-1 and increased HSP90 expression in skeletal muscle in subjects with type 2 diabetes or impaired glucose tolerance.BioMed research international · 2014Article
- Oxidative stress as an underlying contributor in the development of chronic complications in diabetes mellitus.International journal of molecular sciences · 2013Article
- Oxidative DNA damage in early pregnancy and risk of gestational diabetes mellitus: A pilot study.Clinical biochemistry · 2011Article
- Remnant B-cell-stimulative and anti-oxidative effects of Persea americana fruit extract studied in rats introduced into streptozotocin - induced hyperglycaemic state.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2011Article
- Intermittent high glucose enhances apoptosis in INS-1 cells.Experimental diabetes research · 2011Article
- Effect of oral acetyl L-carnitine arginate on resting and postprandial blood biomarkers in pre-diabetics.Nutrition & metabolism · 2009Article
- Systemic oxidative stress is increased to a greater degree in young, obese women following consumption of a high fat meal.Oxidative medicine and cellular longevityArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsType 2 diabetes is preceded by a symptom-free period of impaired glucose tolerance (IGT). Pancreatic B-cell function decreases as glucose intolerance develops. In many patients with IGT, fasting blood glucose is within normal limits and hyperglycaemia occurs only postprandially. We examined whether pancreatic B-cell function changes during acute hyperglycaemia induced by oral glucose loading.
methodsWe calculated the insulinogenic index (I.I.) as an indicator of pancreatic B-cell function and measured serum levels of thioredoxin, a marker of cellular redox state, and 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of oxidative stress, during a 75-g oral glucose tolerance test (OGTT) in 45 subjects [24 patients with normal glucose tolerance (NGT), 14 with IGT and seven with Type 2 diabetes].
resultsThioredoxin levels decreased after glucose loading [66.1 +/- 23.7, *59.3 +/- 22.4, *49.3 +/- 21.2 and *37.7 +/- 18.0 ng/ml, fasting (0 min) and at 30, 60 and 120 min, respectively; *P < 0.001 vs. fasting]. In contrast, concentrations of 8-OHdG peaked at 30 min and then gradually decreased (0.402 +/- 0.123, *0.440 +/- 0.120, 0.362 +/- 0.119 and 0.355 +/- 0.131 ng/ml, *P < 0.05 vs. fasting, P < 0.01 vs. 30 min). The insulinogenic index correlated with the change in thioredoxin levels (r = 0.34, P < 0.05). However, there was no relationship with the change in 8-OHdG levels from 0 to 30 min.
conclusionsHyperglycaemia in response to oral glucose impairs pancreatic B-cell function with decreasing thioredoxin levels. The augmented oxidative stress induced by hyperglycaemia may affect the cellular redox state. These findings strongly suggest that repeated postprandial hyperglycaemia may play an important role in the development and progression of diabetes mellitus.
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