ArticleThe EMBO journal2007
A cell cycle-dependent co-repressor mediates photoreceptor cell-specific nuclear receptor function.
Article in The EMBO journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 47 citations in OpenAlex.
- Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-γ (PPARγ) are disrupted by retinal disease-associated mutations.Cell death & disease · 2017Article
- Co-activator candidate interactions for orphan nuclear receptor NR2E1.BMC genomics · 2016Article
- Differential dimerization of variants linked to enhanced S-cone sensitivity syndrome (ESCS) located in the NR2E3 ligand-binding domain.Human mutation · 2015Article
- IL-13Rα2 mediates PNR-induced migration and metastasis in ERα-negative breast cancer.Oncogene · 2015Article
- Structural basis for corepressor assembly by the orphan nuclear receptor TLX.Genes & development · 2015Article
- Structural insights into gene repression by the orphan nuclear receptor SHP.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.Nucleic acids research · 2013Article
- In pursuit of synthetic modulators for the orphan retina-specific nuclear receptor NR2E3.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2013Article
- The crystal structure of the orphan nuclear receptor NR2E3/PNR ligand binding domain reveals a dimeric auto-repressed conformation.PloS one · 2013Article
- Article
- Tbl3 regulates cell cycle length during zebrafish development.Developmental biology · 2012Article
- Epigeneitc silencing of ribosomal RNA genes by Mybbp1a.Journal of biomedical science · 2012Article
- Minireview: the role of nuclear receptors in photoreceptor differentiation and disease.Molecular endocrinology (Baltimore, Md.) · 2012Review
- Epigenetic silencing of myogenic gene program by Myb-binding protein 1a suppresses myogenesis.The EMBO journal · 2012Article
- Orphan nuclear receptor PNR/NR2E3 stimulates p53 functions by enhancing p53 acetylation.Molecular and cellular biology · 2012Article
- Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer.EMBO molecular medicine · 2012Article
- Article
- Nuclear receptor Rev-erb alpha (Nr1d1) functions in concert with Nr2e3 to regulate transcriptional networks in the retina.PloS one · 2011Article
- Phosphorylation of Williams syndrome transcription factor by MAPK induces a switching between two distinct chromatin remodeling complexes.The Journal of biological chemistry · 2009Article
- Article
Corrections and comments
- Retraction · 2014-12-01Concerns/Issues about Image · Error in Image · Investigation by Company/Institution ·
- Retracted
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photoreceptor cell-specific nuclear receptor (PNR) (NR2E3) acts as a sequence-specific repressor that controls neuronal differentiation in the developing retina. We identified a novel PNR co-repressor, Ret-CoR, that is expressed in the developing retina and brain. Biochemical purification of Ret-CoR identified a multiprotein complex that included E2F/Myb-associated proteins, histone deacetylases (HDACs) and NCoR/HDAC complex-related components. Ret-CoR appeared to function as a platform protein for the complex, and interacted with PNR via two CoRNR motifs. Purified Ret-CoR complex exhibited HDAC activity, co-repressed PNR transrepression function in vitro, and co-repressed PNR function in PNR target gene promoters, presumably in the retinal progenitor cells. Notably, the appearance of Ret-CoR protein was cell-cycle-stage-dependent (from G1 to S). Therefore, Ret-CoR appears to act as a component of an HDAC co-repressor complex that supports PNR repression function in the developing retina, and may represent a co-regulator class that supports transcriptional regulator function via cell-cycle-dependent expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.