ArticleThe American journal of pathology2007
Proangiogenic role of ephrinB1/EphB1 in basic fibroblast growth factor-induced corneal angiogenesis.
Article in The American journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Targeting tumor innervation: premises, promises, and challenges.Cell death discovery · 2022Review
- Cancer exosomes induce tumor innervation.Nature communications · 2018Article
- Identification of specifically activated angiogenic molecules in HMGB-1-induced angiogenesis.BMB reports · 2017Article
- Derivation of Functional Human Astrocytes from Cerebral Organoids.Scientific reports · 2017Article
- Inhibition of lymphangiogenesis in vitro and in vivo by the multikinase inhibitor nintedanib.Drug design, development and therapy · 2017Article
- Molecular underpinnings of corneal angiogenesis: advances over the past decade.International journal of ophthalmology · 2016Review
- Partial denervation of sub-basal axons persists following debridement wounds to the mouse cornea.Laboratory investigation; a journal of technical methods and pathology · 2015Article
- Spontaneous reversion of the angiogenic phenotype to a nonangiogenic and dormant state in human tumors.Molecular cancer research : MCR · 2014Article
- Wounding the cornea to learn how it heals.Experimental eye research · 2014Review
- EphB4 expression in pterygium is associated with microvessel density.International journal of clinical and experimental medicine · 2014Article
- Inhibition of choroidal neovascularization by anti-EphB4 monoclonal antibody.Experimental and therapeutic medicine · 2013Article
- MT1-MMP cleavage of the antiangiogenic proteoglycan decorin: role in corneal angiogenesis.Cornea · 2011Article
- Platelet-derived growth factor-DD targeting arrests pathological angiogenesis by modulating glycogen synthase kinase-3beta phosphorylation.The Journal of biological chemistry · 2010Article
- Novel aspects of corneal angiogenic and lymphangiogenic privilege.Progress in retinal and eye research · 2010Review
- Corneal epithelial MT1-MMP inhibits vascular endothelial cell proliferation and migration.Cornea · 2010Article
- The aortic ring model of angiogenesis: a quarter century of search and discovery.Journal of cellular and molecular medicine · 2009Review
- MT1-MMP-mediated cleavage of decorin in corneal angiogenesis.Journal of vascular research · 2009Article
- Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.International journal of cancer · 2008Article
- In vitro assays of angiogenesis for assessment of angiogenic and anti-angiogenic agents.Microvascular researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Corneal neovascularization is a vision-threatening condition caused by various ocular pathological conditions. The aim of this study was to evaluate the function of the ephrin ligands and Eph receptors in vitro and in vivo in corneal angiogenesis in a mouse model. The Eph tyrosine kinase receptors and their ligands, ephrins, are expressed on the cell surface. The functions of Eph and ephrins have been shown to regulate axonal guidance, segmentation, cell migration, and angiogenesis. Understanding the roles of Eph and ephrin in corneal angiogenesis may provide a therapeutic intervention for the treatment of angiogenesis-related disorders. Immunohistochemical studies demonstrated that ephrinB1 and EphB1 were expressed in basic fibroblast growth factor (bFGF)-induced vascularized corneas. EphB1 was specifically colocalized with vascular endothelial marker CD31 surrounded by type IV collagen. EphrinB1 was expressed in corneal-resident keratocytes and neutrophils. Recombinant ephrinB1-Fc, which induces EphB receptor activation, enhanced bFGF-induced tube formation in an in vitro aortic ring assay and promoted bFGF-induced corneal angiogenesis in vivo in a corneal pocket assay. Synergistically enhanced and sustained activation of extracellular signal-regulated kinase was noted in vascular endothelial cell lines after stimulation with ephrin B1 and bFGF combinations. These results suggest that ephrinB1 plays a synergistic role in corneal neovascularization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.