ArticleThe American journal of pathology2007
Tumor signaling to the bone marrow changes the phenotype of monocytes and pulmonary macrophages during urethane-induced primary lung tumorigenesis in A/J mice.
Article in The American journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 69 citations in OpenAlex.
- Mitochondrial VDAC1 Silencing in Urethane-Induced Lung Cancer Inhibits Tumor Growth and Alters Cancer Oncogenic Properties.Cancers · 2024Article
- Intranasal Iloprost Prevents Tumors in a Murine Lung Carcinogenesis Model.Cancer prevention research (Philadelphia, Pa.) · 2022Article
- An Improved Murine Premalignant Squamous Cell Model: Tobacco Smoke Exposure Augments NTCU-Induced Murine Airway Dysplasia.Cancer prevention research (Philadelphia, Pa.) · 2021Article
- Two-stage 3-methylcholanthrene and butylated hydroxytoluene-induced lung carcinogenesis in mice.Methods in cell biology · 2021Article
- Directionality of Macrophages Movement in Tumour Invasion: A Multiscale Moving-Boundary Approach.Bulletin of mathematical biology · 2020Article
- Gas6/MerTK signaling is negatively regulated by NF-κB and supports lung carcinogenesis.Oncotarget · 2019Article
- In-vitro and in-vivo difference in gene delivery by lithocholic acid-polyethyleneimine conjugate.Biomaterials · 2019Article
- A Gene Expression Classifier from Whole Blood Distinguishes Benign from Malignant Lung Nodules Detected by Low-Dose CT.Cancer research · 2019Article
- Immune Surveillance by Natural IgM Is Required for Early Neoantigen Recognition and Initiation of Adaptive Immunity.American journal of respiratory cell and molecular biology · 2018Article
- Myeloid STAT3 Promotes Lung Tumorigenesis by Transforming Tumor Immunosurveillance into Tumor-Promoting Inflammation.Cancer immunology research · 2017Article
- Epiregulin is required for lung tumor promotion in a murine two-stage carcinogenesis model.Molecular carcinogenesis · 2017Article
- Expression of Chemokine XCL2 and CX3CL1 in Lung Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Differential innate immune cell signatures and effects regulated by toll-like receptor 4 during murine lung tumor promotion.Experimental lung research · 2016Article
- AKT1E¹⁷K Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer.PloS one · 2016Article
- Depletion of tumor-associated macrophages slows the growth of chemically induced mouse lung adenocarcinomas.Frontiers in immunology · 2014Article
- Promoting effect of neutrophils on lung tumorigenesis is mediated by CXCR2 and neutrophil elastase.Molecular cancer · 2013Article
- MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis.The Journal of clinical investigation · 2013Article
- ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages.Cell research · 2013Article
- Article
- Enhancement of lung tumorigenesis in a Gprc5a Knockout mouse by chronic extrinsic airway inflammation.Molecular cancer · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Little is known about how the composition of stromal cells within the lung cancer microenvironment varies during tumor progression. We examined by immunohistochemistry each of six different stromal cell populations during the development of chemically induced primary lung cancer in mice. Blood vessels were seen even in microscopic lesions, and their numbers increased with tumor size. Neutrophils infiltrated the alveoli of tumor-bearing lungs and within the periphery of macroscopic adenomas and adenocarcinomas. The numbers of peritumoral lymphocytes and macrophages increased during oncogeny, but quantitative changes in mast cells and fibroblasts were not evident. Because macrophage depletion reduces tumor growth and these cells are thus important to tumorigenesis, we also investigated their phenotype. Pulmonary macrophages expressed arginase I (subtype M2) but not inducible nitric-oxide synthase in lungs with premalignant lesions, whereas macrophages in carcinoma-bearing lungs expressed inducible nitric-oxide synthase (subtype M1) but not arginase I. Local pulmonary stimuli did not seem responsible for this shift in macrophage activation state because monocytes still residing within the bone marrow adopted these expression patterns before entering the circulation, presumably in response to tumor-derived signals. These biochemical markers of macrophage activation states would have diagnostic and/or therapeutic value if analogous systemic shifts occur in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.