ArticleThe American journal of pathology2007
Exacerbated pathology of viral encephalitis in mice with central nervous system-specific autoantibodies.
Article in The American journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Phenotypic characteristics of myelin oligodendrocyte glycoprotein antibody-associated disease in children: a single-center, retrospective study.Frontiers in neurology · 2023Article
- Viral Clearance and Neuroinflammation in Acute TMEV Infection Vary by Host Genetic Background.International journal of molecular sciences · 2022Article
- Neuroinflammatory Disease following Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children.The Journal of pediatrics · 2022Article
- Case report: MOG-IgG-associated encephalitis with Epstein-Barr virus infection and Alzheimer's pathologic change in cerebrospinal fluid.Frontiers in neurology · 2022Article
- Article
- Antecedent presentation of neurological phenotypes in the Collaborative Cross reveals four classes with complex sex-dependencies.Scientific reports · 2020Article
- Myelin oligodendrocyte glycoprotein antibodies in neurological disease.Nature reviews. Neurology · 2019Review
- Myelin Oligodendrocyte Glycoprotein: Deciphering a Target in Inflammatory Demyelinating Diseases.Frontiers in immunology · 2017Review
- Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System.PLoS pathogens · 2015Article
- The spectrum of MOG autoantibody-associated demyelinating diseases.Nature reviews. Neurology · 2013Review
- Review
- Shuanghuanglian injection downregulates nuclear factor-kappa B expression in mice with viral encephalitis.Neural regeneration research · 2012Article
- IgG glycan hydrolysis by EndoS inhibits experimental autoimmune encephalomyelitis.Journal of neuroinflammation · 2012Article
- Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis.Journal of neuroinflammation · 2011Article
- The pathogenesis of murine coronavirus infection of the central nervous system.Critical reviews in immunology · 2010Review
- The Biology of Persistent Infection: Inflammation and Demyelination following Murine Coronavirus Infection of the Central Nervous System.Current immunology reviews · 2009Article
- Anti-viral T-cell immunity+anti-CNS autoantibody=a model for human acute disseminated encephalomyelitis or multiple sclerosis relapse?The American journal of pathology · 2007Article
- Postinfectious Acute Disseminated Encephalomyelitis Associated With Antimyelin Oligodendrocyte Glycoprotein Antibody.Child neurology openArticle
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7 authors at 3 institutions in 2 countries.
Funding
Abstract
We examine here the outcome of viral encephalomyelitis [mouse hepatitis virus (MHV) A59, Theiler's encephalomyelitis virus, and Coxsackievirus B3] in mice with autoantibodies to a central nervous system (CNS)-specific antigen, myelin oligodendrocyte glycoprotein, that usually develop no clinical disease. Morbidity and mortality of the acute viral CNS disease was augmented by the presence of the autoantibodies in all three viral infections. Transfer of serum containing the autoantibodies at the time of infection with MHV was sufficient to reproduce the exacerbated disease. The presence of the autoantibodies was found to result in increased infiltration of mononuclear cells into the brain. Early demyelination was severely augmented in brains and spinal cords of MHV-infected mice with CNS-specific autoantibodies. The antibody-mediated exacerbation was shown to be independent of the complement system but to require expression of Fc receptors, because it was observed in C'-3-deficient but not in Fc receptor-deficient mice. Our study illustrates the possibility that infections can lead to much more profound immunopathology in the presence of an otherwise latent autoimmune condition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.