Evidence map›Paper›PMID 17255119›Full record

ArticleSchizophrenia bulletin2007

North American Prodrome Longitudinal Study: a collaborative multisite approach to prodromal schizophrenia research.

Jean Addington, Kristin S Cadenhead, Tyrone D Cannon, Barbara Cornblatt, Thomas H McGlashan, Diana O Perkins, Larry J Seidman, Ming Tsuang, Elaine F Walker, Scott W Woods and 2 more

Registry-linked trialAbstract readMulticenter Study
In one paragraph

Article in Schizophrenia bulletin, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02459210 (CLUES), which is not on this map. Cited by 129 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02459210 nacompletednot on this mapstarted 2015, after this paper: background citation

CLUES (Cognition for Learning and for Understanding Everyday Social Situations): An Adaptation of Cognitive Enhancement Therapy for Persons at Clinical High Risk for Psychosis

TypeinterventionalSponsorBeth Israel Deaconess Medical CenterRan2015 to 2019Enrolled58ConditionsPsychosisArmsCLUES, therapy and computer games
3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2013
    Trial
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  13. Exploring causal mechanisms of psychosis risk.Neuroscience and biobehavioral reviews · 2024
    Review
  14. Article
  15. Article
  16. Article
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  18. Review
  19. Article
  20. Article

69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jean AddingtonCentre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada. jean_addington@camh.net
Kristin S Cadenhead
Tyrone D Cannon
Barbara Cornblatt
Thomas H McGlashan
Diana O Perkins
Larry J Seidman
Ming Tsuang
Elaine F Walker
Scott W Woods
Robert Heinssen
North American Prodrome Longitudinal Study

Funding

5/9 Predictors and Mechanisms of Conversion to PsychosisU01MH082004 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PERKINS, DIANA O. · 2008 to 2018
$7.5M
8/9 Predictors and Mechanisms of Conversion to PsychosisU01MH082022 · NIMH · YALE UNIVERSITY · PI WOODS, SCOTT W · 2008 to 2018
$6.0M
6/9-Predictors and Mechanisms of Conversion to PsychosisU01MH081944 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CADENHEAD, KRISTIN S. · 2008 to 2018
$4.9M
VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIAR01MH060720 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CADENHEAD, KRISTIN S. · 2000 to 2010
$4.0M
INTERVENING AT PRODROMAL STAGES OF PSYCHOSISK23MH001905 · NIMH · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI PERKINS, DIANA O. · 2000 to 2004
$826k
NIMH NIH HHS K23 MH001905NIMH NIH HHS R01 MH060720NIMH NIH HHS U01 MH081944NIMH NIH HHS U01 MH082004NIMH NIH HHS U01 MH082022
6 · The paper itself

Abstract

This article presents the rationale, design, and preliminary findings of the North American Prodrome Longitudinal Study (NAPLS), a collaborative, multisite investigation into the earliest phase of psychotic illness. We describe how 8 independently conceived research projects were integrated methodologically, how diagnostic reliability was achieved across sites on the Structured Interview for Prodromal Syndromes, and how baseline and follow-up data were aggregated for 888 at risk and comparison subjects. Data are presented describing the demographic, academic/work, and diagnostic characteristics of 3 relevant subgroups: persons at heightened clinical risk for psychosis, help-seeking comparison subjects, and nonpsychiatric controls. The NAPLS data set will be used to explore a series of questions related to prodromal psychosis, including the descriptive phenomenology of currently accepted diagnostic criteria, conversion rates over a 30-month period, predictors of psychosis onset and functional disability, and the impact of early treatment on the course of prodromal symptoms.

Indexed as

Cooperative BehaviorResearchSchizophrenic PsychologyAdolescentAdultFemaleHumansLongitudinal StudiesMaleMeta-Analysis as TopicMulticenter Studies as TopicNorth AmericaOutcome Assessment, Health CareResearch DesignRisk FactorsSchizophrenia

Identifiers

PMID17255119
PMCPMC2526151

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.