ArticleClinical and molecular allergy : CMA2007
Immune response modulation by curcumin in a latex allergy model.
Article in Clinical and molecular allergy : CMA, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 81 citations in OpenAlex.
- Current State of Scientific Knowledge on Curcumin Encapsulation and Applications.Recent advances in food, nutrition & agriculture · 2025Review
- Therapeutic Efficacy of Curcumin Enhanced by Microscale Discoidal Polymeric Particles in a Murine Asthma Model.Pharmaceutics · 2020Article
- Animal models of asthma: utility and limitations.Journal of asthma and allergy · 2017Review
- Curcumin Ingestion Inhibits Mastocytosis and Suppresses Intestinal Anaphylaxis in a Murine Model of Food Allergy.PloS one · 2015Article
- Curcumin a potent cancer preventive agent: Mechanisms of cancer cell killing.Interventional medicine & applied science · 2014Review
- Evaluation of Efficacy of Curcumin as an Add-on therapy in Patients of Bronchial Asthma.Journal of clinical and diagnostic research : JCDR · 2014Article
- Discovery and evaluation of novel anti-inflammatory derivatives of natural bioactive curcumin.Drug design, development and therapy · 2014Article
- Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers.British journal of pharmacology · 2013Review
- The Ethanol Extract of Osmanthus fragrans Flowers Reduces Oxidative Stress and Allergic Airway Inflammation in an Animal Model.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Curcumin suppresses ovalbumin-induced allergic conjunctivitis.Molecular vision · 2012Article
- Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles.International journal of nanomedicine · 2012Article
- Curcumin in stevens-johnsons syndrome: culprit or bystander?The World Allergy Organization journal · 2009Article
- Inhibition of human dendritic cell activation by hydroethanolic but not lipophilic extracts of turmeric (Curcuma longa).Planta medica · 2009Article
- Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.The international journal of biochemistry & cell biology · 2009Review
- The antioxidant response element and oxidative stress modifiers in airway diseases.Current molecular medicine · 2008Review
- A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95CG (Biocurcumax), A Novel Bioenhanced Preparation of Curcumin.Indian journal of pharmaceutical sciencesArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere has been a worldwide increase in allergy and asthma over the last few decades, particularly in industrially developed nations. This resulted in a renewed interest to understand the pathogenesis of allergy in recent years. The progress made in the pathogenesis of allergic disease has led to the exploration of novel alternative therapies, which include herbal medicines as well. Curcumin, present in turmeric, a frequently used spice in Asia has been shown to have anti-allergic and inflammatory potential.
methodsWe used a murine model of latex allergy to investigate the role of curcumin as an immunomodulator. BALB/c mice were exposed to latex allergens and developed latex allergy with a Th2 type of immune response. These animals were treated with curcumin and the immunological and inflammatory responses were evaluated.
resultsAnimals exposed to latex showed enhanced serum IgE, latex specific IgG1, IL-4, IL-5, IL-13, eosinophils and inflammation in the lungs. Intragastric treatment of latex-sensitized mice with curcumin demonstrated a diminished Th2 response with a concurrent reduction in lung inflammation. Eosinophilia in curcumin-treated mice was markedly reduced, co-stimulatory molecule expression (CD80, CD86, and OX40L) on antigen-presenting cells was decreased, and expression of MMP-9, OAT, and TSLP genes was also attenuated.
conclusionThese results suggest that curcumin has potential therapeutic value for controlling allergic responses resulting from exposure to allergens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.