Evidence map›Paper›PMID 17254316›Full record

ReviewArthritis research & therapy2006

Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis.

Kutty Selva Nandakumar, Rikard Holmdahl

Open access · goldAbstract readReview
In one paragraph

Review in Arthritis research & therapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
6.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 129 citations in OpenAlex.

  1. Article
  2. Review
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  14. Vitamin D3 receptor polymorphisms regulate T cells and T cell-dependent inflammatory diseases.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
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  19. Article
  20. Cleavage Region Thyrotropin Receptor Antibodies Influence Thyroid Cell SurvivalThyroid : official journal of the American Thyroid Association · 2019
    Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kutty Selva NandakumarMedical Inflammation Research, Lund University, Lund 22184, Sweden. nan@med.lu.se
Rikard Holmdahl
Lund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the development of rheumatoid arthritis (RA) autoantibodies to IgG-Fc, citrullinated proteins, collagen type II (CII), glucose 6 phosphoisomerase (G6PI) and some other self-antigens appear. Of these, a pathogenic effect of the anti-CII and anti-G6PI antibodies is well demonstrated using animal models. These new antibody mediated arthritis models have proven to be very useful for studies involved in understanding the molecular pathways of the induction of arthritis in joints. Both the complement and FcgammaR systems have been found to play essential roles. Neutrophils and macrophages are important inflammatory cells and the secretion of tumour necrosis factor-alpha and IL-1beta is pathogenic. The identification of the genetic polymorphisms predisposing to arthritis is important for understanding the complexity of arthritis. Disease mechanisms and gene regions studied using the two antibody-induced arthritis mouse models (collagen antibody-induced arthritis and serum transfer-induced arthritis) are compared and discussed for their relevance in RA pathogenesis.

Indexed as

Genetic Predisposition to DiseaseAnimalsAntibodiesAntibodies, MonoclonalAntibody SpecificityArthritis, ExperimentalArthritis, RheumatoidAutoantibodiesB-LymphocytesDisease Models, AnimalGenetic MarkersGlucose-6-Phosphate IsomeraseMiceMice, Inbred DBAMice, TransgenicReceptors, Antigen, T-CellAntibodiesAntibodies, MonoclonalAutoantibodiesGenetic MarkersGlucose-6-Phosphate IsomeraseReceptors, Antigen, T-CellRheumatoid FactorTumor Necrosis Factor-alpha

Identifiers

PMID17254316
PMCPMC1794524
OpenAlexW1542422583

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.