ArticleBMC bioinformatics2006
Large-scale analysis of antigenic diversity of T-cell epitopes in dengue virus.
Article in BMC bioinformatics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 58 citations in OpenAlex.
- Peptide MegaPools Approach to Evaluate the Dengue-Specific CD4 and CD8 T-Cell Response.Pathogens (Basel, Switzerland) · 2025Article
- An Alignment-Independent Approach for the Study of Viral Sequence Diversity at Any Given Rank of Taxonomy Lineage.Biology · 2021Article
- Identification and selection of immunodominant B and T cell epitopes for dengue multi-epitope-based vaccine.Medical microbiology and immunology · 2021Review
- Probability of consolidation constrains novel serotype emergence in dengue fever virus.PloS one · 2021Article
- Analysis of viral diversity for vaccine target discovery.BMC medical genomics · 2017Article
- Flaviviral NS4b, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention.Reviews in medical virology · 2015Review
- g-FLUA2H: a web-based application to study the dynamics of animal-to-human mutation transmission for influenza viruses.BMC medical genomics · 2015Article
- A highly conserved region between amino acids 221 and 266 of dengue virus non-structural protein 1 is a major epitope region in infected patients.The American journal of tropical medicine and hygiene · 2014Article
- Identification of conserved and HLA promiscuous DENV3 T-cell epitopes.PLoS neglected tropical diseases · 2013Article
- Dissecting the dynamics of HIV-1 protein sequence diversity.PloS one · 2013Article
- Antigenic heterogeneity of capsid protein VP1 in foot-and-mouth disease virus (FMDV) serotype Asia 1.Advances and applications in bioinformatics and chemistry : AABC · 2013Article
- The development of Chinese specific human cytomegalovirus polyepitope recombinant vaccine.Antiviral research · 2012Article
- Mouse STAT2 restricts early dengue virus replication.Cell host & microbe · 2010Article
- Article
- Immunoinformatics: current trends and future directions.Drug discovery today · 2009Review
- Conservation and variability of dengue virus proteins: implications for vaccine design.PLoS neglected tropical diseases · 2008Article
- Hotspot Hunter: a computational system for large-scale screening and selection of candidate immunological hotspots in pathogen proteomes.BMC bioinformatics · 2008Article
- A systematic bioinformatics approach for selection of epitope-based vaccine targets.Cellular immunology · 2006Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundAntigenic diversity in dengue virus strains has been studied, but large-scale and detailed systematic analyses have not been reported. In this study, we report a bioinformatics method for analyzing viral antigenic diversity in the context of T-cell mediated immune responses. We applied this method to study the relationship between short-peptide antigenic diversity and protein sequence diversity of dengue virus. We also studied the effects of sequence determinants on viral antigenic diversity. Short peptides, principally 9-mers were studied because they represent the predominant length of binding cores of T-cell epitopes, which are important for formulation of vaccines.
resultsOur analysis showed that the number of unique protein sequences required to represent complete antigenic diversity of short peptides in dengue virus is significantly smaller than that required to represent complete protein sequence diversity. Short-peptide antigenic diversity shows an asymptotic relationship to the number of unique protein sequences, indicating that for large sequence sets (approximately 200) the addition of new protein sequences has marginal effect to increasing antigenic diversity. A near-linear relationship was observed between the extent of antigenic diversity and the length of protein sequences, suggesting that, for the practical purpose of vaccine development, antigenic diversity of short peptides from dengue virus can be represented by short regions of sequences (approximately <100 aa) within viral antigens that are specific targets of immune responses (such as T-cell epitopes specific to particular human leukocyte antigen alleles).
conclusionThis study provides evidence that there are limited numbers of antigenic combinations in protein sequence variants of a viral species and that short regions of the viral protein are sufficient to capture antigenic diversity of T-cell epitopes. The approach described herein has direct application to the analysis of other viruses, in particular those that show high diversity and/or rapid evolution, such as influenza A virus and human immunodeficiency virus (HIV).
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