SynthesisThe Cochrane database of systematic reviews2007
Cholecystectomy versus no cholecystectomy in patients with silent gallstones.
Synthesis in The Cochrane database of systematic reviews, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Evidence-based clinical practice guidelines for cholelithiasis 2016.Journal of gastroenterology · 2017Guideline
- Cholecystectomy versus no cholecystectomy in patients with silent gallstones.The Cochrane database of systematic reviews · 2007Pooled it
- Gallbladder Cancer: Epidemiology and Prevention.Cancers · 2026Review
- Sex-specific associations of SHBG, testosterone, and obesity with cholecystectomy risk: a population-based cohort study.Biology of sex differences · 2026Article
- Article
- Asymptomatic gallstone disease: Re-evaluating the threshold for surgical options in the era of precision medicine.World journal of gastrointestinal surgery · 2025Review
- Gallstone disease, diabetes, calcium, triglycerides, smoking and alcohol consumption and pancreatitis risk: Mendelian randomization study.NPJ genomic medicine · 2021Article
- Is It Safe to Recommend Cholecystectomy Whenever Gallstones Develop After Bariatric Surgery?Obesity surgery · 2021Article
- Risk factors of systematic biliary complications in patients with gallbladder stones.Irish journal of medical science · 2020Article
- Laparoscopic cholecystectomy: consensus conference-based guidelines.Langenbeck's archives of surgery · 2015Review
- Gallstones in patients with liver cirrhosis: incidence, etiology, clinical and therapeutical aspects.World journal of gastroenterology · 2014Review
- Asymptomatic Gallstones (AsGS) - To Treat or Not to?The Indian journal of surgery · 2012Article
- Endoscopic management of post-cholecystectomy biliary fistula.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2011Article
- Is laparoscopic cholecystectomy more challenging in male patients?Surgical endoscopy · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCholecystectomy is currently advised only for patients with symptomatic gallstones. However, about 4% of patients with asymptomatic gallstones develop symptoms including cholecystitis, obstructive jaundice, pancreatitis, and gallbladder cancer.
objectivesTo assess the benefits and harms of surgical removal of the gallbladder for patients with asymptomatic gallstones. SEARCH STRATEGY: We searched The Cochrane Hepato-Biliary Group Controlled Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, MEDLINE, EMBASE, and Science Citation Index Expanded until 2006 for identifying the randomised trials using The Cochrane Hepato-Biliary Group search strategy. SELECTION CRITERIA: Only randomised clinical trials (irrespective of language, blinding, or publication status) comparing cholecystectomy and no cholecystectomy were considered for the review. DATA COLLECTION AND ANALYSIS: We were unable to identify any randomised clinical trials comparing cholecystectomy versus no cholecystectomy. MAIN
resultsWe were unable to identify any randomised clinical trial comparing cholecystectomy versus no cholecystectomy. AUTHORS'
conclusionsThere are no randomised trials comparing cholecystectomy versus no cholecystectomy in patients with silent gallstones. Further evaluation of observational studies, which measure outcomes such as obstructive jaundice, gallstone-associated pancreatitis, and/or gall-bladder cancer for sufficient duration of follow-up is necessary before randomised trials are designed in order to evaluate whether cholecystectomy or no cholecystectomy is better for asymptomatic gallstones.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.