SynthesisThe Cochrane database of systematic reviews2007
H1-antihistamines for the treatment of anaphylaxis with and without shock.
Synthesis in The Cochrane database of systematic reviews, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Systematic review of outcome measures in trials of pediatric anaphylaxis treatment.BMC pediatrics · 2014Pooled it
- Glucocorticoids for the treatment of anaphylaxis.The Cochrane database of systematic reviews · 2012Pooled it
- Trial
- Management Strategy for Anaphylaxis in a Patient With Suspected or Confirmed Mastocytosis: A Case Report.The American journal of case reports · 2026Article
- Anaphylaxis management in a French pediatric emergency department: Lessons from the ANA-PED study.Clinical and translational allergy · 2023Article
- Hypertensive and Hypotensive Emergencies in Interventional Radiology.Seminars in interventional radiology · 2022Review
- Anaphylaxis Presenting as Uvulitis.Cureus · 2021Article
- Voltage-dependent modulation of TRPA1 currents by diphenhydramine.Cell calcium · 2020Article
- Knowledge and attitude toward anaphylaxis during local anesthesia among dental practitioners in Chennai - a cross-sectional study.Clinical, cosmetic and investigational dentistry · 2018Article
- Use of Epinephrine in Patients with Drug-Induced Anaphylaxis: An Analysis of the Beijing Pharmacovigilance Database.International archives of allergy and immunology · 2017Article
- Anaphylaxis in the acute care setting.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2014Review
- Anaphylaxis in children: current understanding and key issues in diagnosis and treatment.Current allergy and asthma reports · 2012Review
- Fish-oil capsule ingestion: a case of recurrent anaphylaxis.Canadian family physician Medecin de famille canadien · 2012Article
- Fatal anaphylaxis to foods: epidemiology, recognition, and prevention.Current allergy and asthma reports · 2009Review
- H1 antihistamines: current status and future directions.The World Allergy Organization journal · 2008Article
- Emergency treatment of anaphylaxis.BMJ (Clinical research ed.) · 2008Article
- [Anaphylaxis in childhood and adolescence].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnaphylaxis is an acute systemic allergic reaction, which can be life-threatening. H1-antihistamines are commonly used as an adjuvant therapy in the treatment of anaphylaxis.
objectivesTo assess the benefits and harm of H1-antihistamines in the treatment of anaphylaxis. SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), (The Cochrane Library), MEDLINE (1966 to June 2006);EMBASE (1966 to June 2006); CINAHL (1982 to June 2006) and ISI Web of Science (1945 to July 2006). We also contacted pharmaceutical companies and international experts in anaphylaxis in an attempt to locate unpublished material. SELECTION CRITERIA: Randomized and quasi-randomized controlled trials comparing H1-antihistamines with placebo or no intervention. DATA COLLECTION AND ANALYSIS: Two authors independently assessed articles for inclusion. MAIN
resultsWe found no studies that satisfied the inclusion criteria. AUTHORS'
conclusionsBased on this review, we are unable to make any recommendations for clinical practice. Randomized controlled trials are needed, although these are likely to prove challenging to design and execute.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.