ArticleDigestive diseases and sciences2007
N-acetyl-L-glutamine, a liquid-stable source of glutamine, partially prevents changes in body weight and on intestinal immunity induced by protein energy malnutrition in pigs.
Article in Digestive diseases and sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Effects of Maternal Pterostilbene Supplementation on Milk Composition and Offspring Gut Antioxidant/Lipid Metabolism in Suckling Piglets: A Multi-Omics Study.Antioxidants (Basel, Switzerland) · 2026Article
- Article
- Post-marketing safety evaluation of Guhong Injection: a multicenter, prospective real-world study of 30,000 cases in China.BMC complementary medicine and therapies · 2025Article
- Alternative microbial-based functional ingredient source for lycopene, beta-carotene, and polyunsaturated fatty acids.Heliyon · 2023Article
- Impact of dietary supplementation of l-Arginine, l-Glutamine, and the combination of both on nursing performance of multiparous sows.Translational animal science · 2023Article
- Chemical composition, pharmacology and pharmacokinetic studies of GuHong injection in the treatment of ischemic stroke.Frontiers in pharmacology · 2023Review
- Comparative metabolomic analysis of polyphenic horn development in the dung beetle Onthophagus taurus.PloS one · 2022Article
- Assessment of genetically modified oilseed rape 73496 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA-GMO-NL-2012-109).EFSA journal. European Food Safety Authority · 2021Article
- A Study on Acetylglutamine Pharmacokinetics in Rat Blood and Brain Based on Liquid Chromatography-Tandem Mass Spectrometry and Microdialysis Technique.Frontiers in pharmacology · 2020Article
- Effect of fermented biogas residue on growth performance, serum biochemical parameters, and meat quality in pigs.Asian-Australasian journal of animal sciences · 2017Article
- Separation and determination of acetyl-glutamine enantiomers by HPLC-MS and its application in pharmacokinetic study.Journal of pharmaceutical analysis · 2017Article
- Glutamine and glutamate: Nonessential or essential amino acids?Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2015Review
- Glutamine and glutamate supplementation raise milk glutamine concentrations in lactating gilts.Journal of animal science and biotechnology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The goal of this study was to evaluate the preventive effect of free glutamine versus N-acetyl-L-glutamine, a liquid-stable source of glutamine, on gut damage induced by protein energy malnutrition in pigs. Healthy pigs (n = 6) were fed a liquid formula for 30 days. Three subgroups of malnourished pigs (n = 6) received daily 20% of the food intake recorded in control group, supplemented with calcium caseinate, glutamine, or N-acetyl-L-glutamine. Body weight was recorded, and small intestinal samples were evaluated for biochemical and immunologic parameters. Suppression in body weight gain was significantly lower in pigs fed with N-acetyl-L-glutamine than in the rest of malnourished pigs. Total number of lymphocytes, CD21+ B cells and CD4+ T cells in ileal Peyer patches were not significantly different in malnourished pigs fed with N-acetyl-L-glutamine and in healthy pigs. In conclusion, N-acetyl-L-glutamine has a moderate protective effect, partially preventing changes induced by protein energy malnutrition.
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