ArticleDigestive diseases and sciences2007
Deoxycholate-induced colitis is markedly attenuated in Nos2 knockout mice in association with modulation of gene expression profiles.
Article in Digestive diseases and sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Regulation of Intestinal Inflammation by Dietary Fats.Frontiers in immunology · 2020Pooled it
- Identification of potential diagnostic markers and molecular mechanisms of asthma and ulcerative colitis based on bioinformatics and machine learning.Frontiers in molecular biosciences · 2025Article
- Jatrorrhizine alleviates ulcerative colitis via regulating gut microbiota and NOS2 expression.Gut pathogens · 2022Article
- Elevated Coefficient of Variation in Total Fecal Bile Acids Precedes Diagnosis of Necrotizing Enterocolitis.Scientific reports · 2020Article
- ABIN1 alleviates inflammatory responses and colitisTherapeutic advances in chronic disease · 2020Article
- Organic Solute Transporter α-β Protects Ileal Enterocytes From Bile Acid-Induced Injury.Cellular and molecular gastroenterology and hepatology · 2018Article
- Protective pathways against colitis mediated by appendicitis and appendectomy.Clinical and experimental immunology · 2011Article
- Carcinogenicity of deoxycholate, a secondary bile acid.Archives of toxicology · 2011Article
- Targeting polyamines and inflammation for cancer prevention.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2011Review
- Maspin is a deoxycholate-inducible, anti-apoptotic stress-response protein differentially expressed during colon carcinogenesis.Clinical and experimental gastroenterology · 2011Article
- Atherogenic diets exacerbate colitis in mice deficient in glutathione peroxidase.Inflammatory bowel diseases · 2010Article
- Current concepts in colorectal cancer prevention.Expert review of gastroenterology & hepatology · 2009Review
- Combination chemoprevention for colon cancer targeting polyamine synthesis and inflammation.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Review
- Deoxycholate, an endogenous cytotoxin/genotoxin, induces the autophagic stress-survival pathway: implications for colon carcinogenesis.Journal of toxicology · 2009Article
- Hydrophobic bile acids, genomic instability, Darwinian selection, and colon carcinogenesis.Clinical and experimental gastroenterology · 2008Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Nos2 knockout mice were compared to wild-type mice for susceptibility to colitis in response to a diet supplemented with deoxycholate, a bile acid increased in the colon of individuals on a high-fat diet. Wild-type mice fed a fat-related diet, supplemented with 0.2% DOC, develop colonic inflammation associated with increases in nitrosative stress, proliferation, oxidative DNA/RNA damage, and angiogenesis, as well as altered expression of numerous genes. However, Nos2 knockout mice fed a diet supplemented with deoxycholate were resistant to these alterations. In particular, 35 genes were identified whose expression was significantly altered at the mRNA level in deoxycholate-fed Nos2(+/+) mice but not in deoxycholate-fed Nos2(-/-) mice. Some of these alterations in NOS2-dependent gene expression correspond to those reported in human inflammatory bowel disease. Overall, our results indicate that NOS2 expression is necessary for the development of deoxycholate-induced colitis in mice, a unique dietary-related model of colitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.