ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2007
Retinoic acid-induced lumbosacral neural tube defects: myeloschisis and hamartoma.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 25 citations in OpenAlex.
- Genes related to neural tube defects and glioblastoma.Scientific reports · 2025Article
- A preliminary investigation of high retinoic acid exposure during fetal development on behavioral competency and litter characteristics in newborn rats.Brain and behavior · 2021Article
- Article
- Spatiotemporal expression of leukemia inhibitory factor receptor protein during neural tube development in embryos with neural tube defects.Neural regeneration research · 2020Article
- MGMT is down-regulated independently of promoter DNA methylation in rats with all-trans retinoic acid-induced spina bifida aperta.Neural regeneration research · 2019Article
- Genetic contribution of retinoid-related genes to neural tube defects.Human mutation · 2018Article
- Identification of PCSK9 as a novel serum biomarker for the prenatal diagnosis of neural tube defects using iTRAQ quantitative proteomics.Scientific reports · 2015Article
- Roles of planar cell polarity pathways in the development of neural [correction of neutral] tube defects.Journal of biomedical science · 2011Review
- Vaults engineered for hydrophobic drug delivery.Small (Weinheim an der Bergstrasse, Germany) · 2011Article
- The old and the new: supratentorial MR findings in Chiari II malformation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2008Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectsTo observe the morphological features of the lumbosacral neural tube defects (NTDs) induced by all-trans retinoic acid (atRA) and to explore the pathogenesis of these defects.
methodsRat embryos with lumbosacral NTDs were obtained by treating pregnant rats with administration of atRA. Rat embryos were obtained by cesarean. Fetuses were sectioned and stained with hematoxylin-eosin (H&E). Relevant structures including caudal neural tube were examined. In the atRA-treated rats, about 48% embryos showed lumbosacral NTDs. There appeared a dorsally and rostrally situated, neural-plate-like structure (myeloschisis) and a ventrally and caudally located cell mass containing multiple canals (hamartoma) in the lumbosacral NTDs induced by atRA.
conclusionsRetinoic acid could disturb the notochord and tail bud development in the process of primary and secondary neurulation in rat embryos, which cause lumbosacral NTDs including myeloschisis and hamartoma. The morphology is very similar to that happens in humans.
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