ArticleVirchows Archiv : an international journal of pathology2007
Expression microarray analysis of papillary thyroid carcinoma and benign thyroid tissue: emphasis on the follicular variant and potential markers of malignancy.
Article in Virchows Archiv : an international journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 45 citations in OpenAlex.
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- Identification of Potential lncRNAs and miRNAs as Diagnostic Biomarkers for Papillary Thyroid Carcinoma Based on Machine Learning.International journal of endocrinology · 2021Article
- Ablation therapy using a low dose of radioiodine may be sufficient in low- to intermediate-risk patients with follicular variant papillary thyroid carcinoma.The Journal of international medical research · 2020Article
- Genetic relationship between Hashimoto`s thyroiditis and papillary thyroid carcinoma with coexisting Hashimoto`s thyroiditis.PloS one · 2020Article
- Uncovering the potential miRNAs and mRNAs in follicular variant of papillary thyroid carcinoma in the Cancer Genome Atlas database.Translational cancer research · 2019Article
- Thyroid follicular adenomas and carcinomas: molecular profiling provides evidence for a continuous evolution.Oncotarget · 2018Article
- Lnc2Catlas: an atlas of long noncoding RNAs associated with risk of cancers.Scientific reports · 2018Article
- Overexpression of SMOC2 Attenuates the Tumorigenicity of Hepatocellular Carcinoma Cells and Is Associated With a Positive Postoperative Prognosis in Human Hepatocellular Carcinoma.Journal of Cancer · 2017Article
- Development of prognostic signatures for intermediate-risk papillary thyroid cancer.BMC cancer · 2016Article
- Differences in miRNA and mRNA Profile of Papillary Thyroid Cancer Variants.International journal of endocrinology · 2016Article
- Article
- Follicular variant of papillary thyroid carcinoma is a unique clinical entity: a population-based study of 10,740 cases.Thyroid : official journal of the American Thyroid Association · 2013Article
- Role of metallothioneins in benign and malignant thyroid lesions.Thyroid research · 2012Article
- High expression of S100A11 in pancreatic adenocarcinoma is an unfavorable prognostic marker.Medical oncology (Northwood, London, England) · 2012Article
- Diagnostic utility of galectin-3 in thyroid cancer.The American journal of pathology · 2010Review
- Thyroid tumours of uncertain malignant potential: frequency and diagnostic reproducibility.Virchows Archiv : an international journal of pathology · 2009Article
- Microarray analysis refines classification of non-medullary thyroid tumours of uncertain malignancy.Oncogene · 2008Article
- A score based on microscopic criteria proposed for analysis of papillary carcinoma of the thyroid.Virchows Archiv : an international journal of pathology · 2008Article
- Utility of malignancy markers in fine-needle aspiration cytology of thyroid nodules: comparison of Hector Battifora mesothelial antigen-1, thyroid peroxidase and dipeptidyl aminopeptidase IV.British journal of cancer · 2008Article
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most common sub-variant of papillary thyroid carcinoma (PTC) is the so-called follicular variant (FVPTC), which is a particularly problematic lesion and can be challenging from a diagnostic viewpoint even in resected lesions. Although fine needle aspiration cytology is very useful in the diagnosis of PTC, its accuracy and utility would be greatly facilitated by the development of specific markers for PTC and its common variants. We used the recently developed Applied Biosystems 1700 microarray system to interrogate a series of 11 benign thyroid lesions and conditions and 14 samples of PTC (six with classic morphology and eight with follicular variant morphology). TaqMan(R) reverse transcriptase-polymerase chain reaction was used to validate the expression portfolios of 50 selected transcripts. Our data corroborates potential biomarkers previously identified in the literature, such as LGALS3, S100A11, LYN, BAX, and cluster of differentiation 44 (CD44). However, we have also identified numerous transcripts never previously implicated in thyroid carcinogenesis, and many of which are not represented on other microarray platforms. Diminished expression of metallothioneins featured strongly among these and suggests a possible role for this family as tumour suppressors in PTC. Fifteen transcripts were significantly associated with FVPTC morphology. Surprisingly, these genes were associated with an extremely narrow repertoire of functions, including the major histocompatibility complex and cathepsin families.
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