ArticleMolecular biology of the cell2007
Retinoblastoma protein regulation by the COP9 signalosome.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Neddylation, an Emerging Mechanism Regulating Cardiac Development and Function.Frontiers in physiology · 2020Review
- Role of the COP9 Signalosome (CSN) in Cardiovascular Diseases.Biomolecules · 2019Review
- COPS2 Antagonizes OCT4 to Accelerate the G2/M Transition of Mouse Embryonic Stem Cells.Stem cell reports · 2018Article
- Article
- Murine Myocardial Transcriptome Analysis Reveals a Critical Role of COPS8 in the Gene Expression of Cullin-RING Ligase Substrate Receptors and Redox and Vesicle Trafficking Pathways.Frontiers in physiology · 2017Article
- The Evolution of COP9 Signalosome in Unicellular and Multicellular Organisms.Genome biology and evolution · 2016Article
- The Evolutionarily Conserved C-terminal Domains in the Mammalian Retinoblastoma Tumor Suppressor Family Serve as Dual Regulators of Protein Stability and Transcriptional Potency.The Journal of biological chemistry · 2015Article
- Genome-Wide Analysis of Drosophila RBf2 Protein Highlights the Diversity of RB Family Targets and Possible Role in Regulation of Ribosome Biosynthesis.G3 (Bethesda, Md.) · 2015Article
- Role of Drosophila retinoblastoma protein instability element in cell growth and proliferation.Cell cycle (Georgetown, Tex.) · 2015Article
- Protection of armadillo/β-Catenin by armless, a novel positive regulator of wingless signaling.PLoS biology · 2014Article
- Integrated stability and activity control of the Drosophila Rbf1 retinoblastoma protein.The Journal of biological chemistry · 2014Article
- Drosophila COP9 signalosome subunit 7 interacts with multiple genomic loci to regulate development.Nucleic acids research · 2014Article
- The eta7/csn3-3 auxin response mutant of Arabidopsis defines a novel function for the CSN3 subunit of the COP9 signalosome.PloS one · 2013Article
- CSN5 specifically interacts with CDK2 and controls senescence in a cytoplasmic cyclin E-mediated manner.Scientific reports · 2013Article
- Ubiquitination of retinoblastoma family protein 1 potentiates gene-specific repression function.The Journal of biological chemistry · 2012Article
- Rbf1 degron dysfunction enhances cellular DNA replication.Cell cycle (Georgetown, Tex.) · 2012Article
- CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1.Protein & cell · 2011Article
- COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation.Cell death and differentiation · 2011Article
- Paradoxical instability-activity relationship defines a novel regulatory pathway for retinoblastoma proteins.Molecular biology of the cell · 2010Article
- Analysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagy.BMC cell biology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Similar to their human counterparts, the Drosophila Rbf1 and Rbf2 Retinoblastoma family members control cell cycle and developmentally regulated gene expression. Increasing evidence suggests that Rbf proteins rely on multiprotein complexes to control target gene transcription. We show here that the developmentally regulated COP9 signalosome (CSN) physically interacts with Rbf2 during embryogenesis. Furthermore, the CSN4 subunit of the COP9 signalosome co-occupies Rbf target gene promoters with Rbf1 and Rbf2, suggesting an active role for the COP9 signalosome in transcriptional regulation. The targeted knockdown of individual CSN subunits leads to diminished Rbf1 and Rbf2 levels and to altered cell cycle progression. The proteasome-mediated destruction of Rbf1 and Rbf2 is increased in cells and embryos with diminished COP9 activity, suggesting that the COP9 signalosome protects Rbf proteins during embryogenesis. Previous evidence has linked gene activation to protein turnover via the promoter-associated proteasome. Our findings suggest that Rbf repression may similarly involve the proteasome and the promoter-associated COP9 signalosome, serving to extend Rbf protein lifespan and enable appropriate programs of retinoblastoma gene control during development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.