ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Development and elimination of endbulb synapses in the chick cochlear nucleus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- Avian cochlear nucleus neurons exhibit tonotopic specializations across development.Journal of neurophysiology · 2026Article
- Auditory hair cells and spiral ganglion neurons regenerate synapses with refined release properties in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Auditory Hair Cells and Spiral Ganglion Neurons Regenerate Synapses with Refined Release Properties In Vitro.bioRxiv : the preprint server for biology · 2023Article
- Tonotopic Specializations in Number, Size, and Reversal Potential of GABAergic Inputs Fine-Tune Temporal Coding at Avian Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Spatiotemporal Analysis of Cochlear Nucleus Innervation by Spiral Ganglion Neurons that Serve Distinct Regions of the Cochlea.Neuroscience · 2020Article
- Tonotopic Differentiation of Coupling between CaiScience · 2019Article
- Functional Development of Principal Neurons in the Anteroventral Cochlear Nucleus Extends Beyond Hearing Onset.Frontiers in cellular neuroscience · 2019Article
- Need for Speed and Precision: Structural and Functional Specialization in the Cochlear Nucleus of the Avian Auditory System.Journal of experimental neuroscience · 2018Review
- Diverse Intrinsic Properties Shape Functional Phenotype of Low-Frequency Neurons in the Auditory Brainstem.Frontiers in cellular neuroscience · 2018Article
- Ion channel mechanisms underlying frequency-firing patterns of the avian nucleus magnocellularis: A computational model.Channels (Austin, Tex.) · 2017Article
- Tonotopic action potential tuning of maturing auditory neurons through endogenous ATP.The Journal of physiology · 2017Article
- Target-specific regulation of presynaptic release properties at auditory nerve terminals in the avian cochlear nucleus.Journal of neurophysiology · 2016Article
- Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Developmental Profile of Ion Channel Specializations in the Avian Nucleus Magnocellularis.Frontiers in cellular neuroscience · 2016Article
- Noradrenergic refinement of glutamatergic neuronal circuits in the lateral superior olivary nucleus before hearing onset.Journal of neurophysiology · 2015Article
- Short-term synaptic depression is topographically distributed in the cochlear nucleus of the chicken.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum.Neuron · 2013Article
- Essential role of postsynaptic NMDA receptors in developmental refinement of excitatory synapses.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Embryonic assembly of auditory circuits: spiral ganglion and brainstem.The Journal of physiology · 2012Article
- Redefining the classification of AMPA-selective ionotropic glutamate receptors.The Journal of physiology · 2012Review
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2 authors at 1 institution in 1 country.
Funding
Abstract
The development of synaptic function was examined at auditory nerve synapses in the rostromedial region of the cochlear nucleus magnocellularis of the chick. EPSCs were studied beginning at embryonic day 12 (E12), when synaptic transmission was first observed, through E19. The amplitude of evoked EPSCs produced by AMPA receptor (AMPA-R) increased 30-fold over this age range, whereas NMDA receptor (NMDA-R)-mediated transmission peaked at E14 and then declined almost completely. At E12, >80% of the miniature EPSCs exhibited both receptor components, and <10% were NMDA-R only. With age, the contribution of NMDA-R to miniature EPSCs steadily declined, suggesting that NMDA-R number is gradually reduced at individual postsynaptic sites. Between E12 and E16, the number of axonal inputs to each cell reduced by half. In simultaneous recordings from adjacent neurons, synchronous EPSCs were observed that resulted from spontaneous firing of the same presynaptic fiber. The difference in amplitude of the EPSCs in the two cells was greater in E14 than E12, whereas at E16 synchronous events were no longer observed, suggesting that the weaker input was destined for elimination. The relative amplitude of the NMDA-R component, compared with the AMPA-R component, was larger for the weaker inputs. When elimination was underway, AMPA-R quantal size was much reduced for the weakest terminals. Thus, elimination of auditory nerve terminals and pruning of axonal branches is preceded by a reduction in quantal efficacy.
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