ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Neural variability, detection thresholds, and information transmission in the vestibular system.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
151 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Galvanic vestibular stimulation for postural rehabilitation in neurological disorders: a systematic review.Frontiers in neuroscience · 2025Pooled it
- From Reflexes to Prediction: Kathleen E. Cullen's Contribution to Modern Vestibular Neuroscience and Clinical Otoneurology-A Conceptual Narrative Review.Audiology research · 2026Review
- Progression of Vestibular Deficits Following Moderate-Intensity Blast Overpressure in Rats.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Acceleration and Velocity Dissociate Temporal Phases of Postural Control in Rhesus Macaques.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Acceleration and Velocity Dissociate Temporal Phases of Postural Control in Rhesus Macaques.bioRxiv : the preprint server for biology · 2026Article
- Multisensory coding of self-motion and its contribution to navigation.Nature reviews. Neuroscience · 2025Review
- Functional contributions of quantal and non-quantal hair cell synaptic transmission in the vestibular periphery.bioRxiv : the preprint server for biology · 2025Article
- Spike Timing-Dependent Plasticity and Random Inputs Shape Interspike Interval Regularity of Model STN Neurons.Biomedicines · 2025Article
- Vestibular Atelectasis: A Narrative Review and Our Experience.Audiology research · 2025Review
- Balance control threshold to vestibular stimuli.The Journal of physiology · 2025Article
- Developmental differentiation of mouse inner ear neuron subpopulations resolved with a peripherin-promoter reporter within the Grm8 locus.Scientific reports · 2025Article
- Differential modification of perceptual thresholds by prolonged near threshold motion in healthy adults and after peripheral lesions.Frontiers in neurology · 2025Article
- Skull vibration induced nystagmus, velocity storage and self-stability.Frontiers in neurology · 2025Article
- Effects of individually calibrated white and pink noise vestibular stimulation on standing balance of young healthy adults.Experimental brain research · 2024Article
- Vestibular afferent neurons develop normally in the absence of quantal/glutamatergic input.Frontiers in neurology · 2024Article
- Differential energetic profile of signal processing in central vestibular neurons.Frontiers in neurology · 2024Article
- Article
- Vestibular Contributions to Primate Neck Postural Muscle Activity during Natural Motion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The Neural Basis for Biased Behavioral Responses Evoked by Galvanic Vestibular Stimulation in Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Muscarinic Acetylcholine Receptors Modulate HCN Channel Properties in Vestibular Ganglion Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
91 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
A fundamental issue in neural coding is the role of spike timing variation in information transmission of sensory stimuli. Vestibular afferents are particularly well suited to study this issue because they are classified as either regular or irregular based on resting discharge variability as well as morphology. Here, we compared the responses of each afferent class to sinusoidal and random head rotations using both information theoretic and gain measures. Information theoretic measures demonstrated that regular afferents transmitted, on average, two times more information than irregular afferents, despite having significantly lower gains. Moreover, consistent with information theoretic measures, regular afferents had angular velocity detection thresholds that were 50% lower than those of irregular afferents (approximately 4 vs 8 degrees/s). Finally, to quantify the information carried by spike times, we added spike-timing jitter to the spike trains of both regular and irregular afferents. Our results showed that this significantly reduced information transmitted by regular afferents whereas it had little effect on irregular afferents. Thus, information is carried in the spike times of regular but not irregular afferents. Using a simple leaky integrate and fire model with a dynamic threshold, we show that differential levels of intrinsic noise can explain differences in the resting discharge, the responses to sensory stimuli, as well as the information carried by action potential timings of each afferent class. Our experimental and modeling results provide new insights as to how neural variability influences the strategy used by two different classes of sensory neurons to encode behaviorally relevant stimuli.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.