ArticleThe Journal of molecular diagnostics : JMD2007
Diagnosis of the small round blue cell tumors using multiplex polymerase chain reaction.
Article in The Journal of molecular diagnostics : JMD, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Ewing's Sarcoma of the Prostate Presenting as Back Pain: A Report of a Rare Case and Review of the Literature.Cureus · 2025Article
- A Perspective on Artificial Intelligence for Molecular Pathologists.The Journal of molecular diagnostics : JMD · 2025Review
- A novel next generation sequencing approach to improve sarcoma diagnosis.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- A Nonpediatric Extraosseous Ewing Sarcoma of the Pancreas: Differential Diagnosis and Therapeutic Strategies.Case reports in oncological medicine · 2020Article
- Development and validation of a robust multiplex serological assay to quantify antibodies specific to pertussis antigens.Biologicals : journal of the International Association of Biological Standardization · 2019Article
- Multi-parameter gene expression profiling of peripheral blood for early detection of hepatocellular carcinoma.World journal of gastroenterology · 2018Article
- Case report: value of gene expression profiling in the diagnosis of atypical neuroblastoma.BMC research notes · 2017Article
- More than meets the eye: the changing face of histopathology.Histopathology · 2017Review
- Prostatic sarcoma of the Ewing family in a 33-year-old male - A case report and review of the literature.Asian journal of urology · 2016Article
- An advanced fragment analysis-based individualized subtype classification of pediatric acute lymphoblastic leukemia.Scientific reports · 2015Article
- SlbHLH068 interacts with FER to regulate the iron-deficiency response in tomato.Annals of botany · 2015Article
- The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation.PLoS genetics · 2014Article
- Article
- A novel multiplex polymerase chain reaction assay for profile analyses of gene expression in peripheral blood.BMC cardiovascular disorders · 2012Article
- Co-overexpression FIT with AtbHLH38 or AtbHLH39 in Arabidopsis-enhanced cadmium tolerance via increased cadmium sequestration in roots and improved iron homeostasis of shoots.Plant physiology · 2012Article
- Murine rhabdomyosarcoma is immunogenic and responsive to T-cell-based immunotherapy.Pediatric blood & cancer · 2011Article
- Custom design of a GeXP multiplexed assay used to assess expression profiles of inflammatory gene targets in normal colon, polyp, and tumor tissue.The Journal of molecular diagnostics : JMD · 2011Article
- Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types.Genes & cancer · 2010Article
- ClpC1, an ATP-dependent Clp protease in plastids, is involved in iron homeostasis in Arabidopsis leaves.Annals of botany · 2010Article
- New Technologies for Diagnosing Pediatric Tumors Expert Opinion on Medical Diagnostics.Expert opinion on medical diagnostics · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The small round blue cell tumors of childhood, which include neuroblastoma, rhabdomyosarcoma, non-Hodgkin's lymphoma, and the Ewing's family of tumors, are so called because of their similar appearance on routine histology. Using cDNA microarray gene expression profiles and artificial neural networks (ANNs), we previously identified 93 genes capable of diagnosing these cancers. Using a subset of these, together with some additional genes (total 39), we developed a multiplex polymerase chain reaction (PCR) assay to diagnose these cancer types. Blinded testing of 96 new samples (26 Ewing's family of tumors, 29 rhabdomyosarcomas, 24 neuroblastomas, and 17 lymphomas) using ANNs in a complete leave-one-out analysis demonstrated that all except one sample were accurately diagnosed as their respective category. Moreover, using an ANN-based gene minimization strategy in a separate analysis, we found that the top 31 genes could correctly diagnose all 96 tumors. Our results suggest that this molecular test based on a multiplex PCR reaction may assist the physician in the rapid confirmation of the diagnosis of these cancers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.