ArticleJournal of virology2007
Spring-loaded heptad repeat residues regulate the expression and activation of paramyxovirus fusion protein.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Spatio-temporal dynamics of Hendra virus in Australia reveal stable maintenance of diverse viral clades among Pteropus bats.Nature microbiology · 2026Article
- Tracking the protein conformational motions driving HIV-1 membrane fusion.Scientific reports · 2026Article
- Article
- Contribution of mutation I142M in fusion protein and Q44R in matrix protein of Newcastle disease virus to virulence in ducks.The Journal of veterinary medical science · 2022Article
- The DI-DII linker of human parainfluenza virus type 3 fusion protein is critical for the virus.Virus genes · 2020Article
- Three genetically distinct ferlaviruses have varying effects on infected corn snakes (Pantherophis guttatus).PloS one · 2019Article
- Quantitative investigation of the direct interaction between Hemagglutinin and fusion proteins of Peste des petits ruminant virus using surface Plasmon resonance.Virology journal · 2018Article
- Cryptic etiopathological conditions of equine nervous system with special emphasis on viral diseases.Veterinary world · 2017Review
- Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis.Journal of virology · 2015Article
- Article
- Influence of antigen insertion site and vector dose on immunogenicity and protective capacity in Sendai virus-based human parainfluenza virus type 3 vaccines.Journal of virology · 2013Article
- Review
- Targeting RSV with vaccines and small molecule drugs.Infectious disorders drug targets · 2012Review
- Coordinate deletion of N-glycans from the heptad repeats of the fusion F protein of Newcastle disease virus yields a hyperfusogenic virus with increased replication, virulence, and immunogenicity.Journal of virology · 2012Article
- Modes of paramyxovirus fusion: a Henipavirus perspective.Trends in microbiology · 2011Review
- Illumination of parainfluenza virus infection and transmission in living animals reveals a tissue-specific dichotomy.PLoS pathogens · 2011Article
- Side chain packing below the fusion peptide strongly modulates triggering of the Hendra virus F protein.Journal of virology · 2010Article
- The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus pathogenicity and transmissibility in ducks.Journal of virology · 2010Article
- Mutations in the ectodomain of newcastle disease virus fusion protein confer a hemagglutinin-neuraminidase-independent phenotype.Journal of virology · 2010Article
- Residues in the heptad repeat a region of the fusion protein modulate the virulence of Sendai virus in mice.Journal of virology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During viral entry, the paramyxovirus fusion (F) protein fuses the viral envelope to a cellular membrane. Similar to other class I viral fusion glycoproteins, the F protein has two heptad repeat regions (HRA and HRB) that are important in membrane fusion and can be targeted by antiviral inhibitors. Upon activation of the F protein, HRA refolds from a spring-loaded, crumpled structure into a coiled coil that inserts a hydrophobic fusion peptide into the target membrane and binds to the HRB helices to form a fusogenic hairpin. To investigate how F protein conformational changes are regulated, we mutated in the Sendai virus F protein a highly conserved 10-residue sequence in HRA that undergoes major structural changes during protein refolding. Nine of the 15 mutations studied caused significant defects in F protein expression, processing, and fusogenicity. Conversely, the remaining six mutations enhanced the fusogenicity of the F protein, most likely by helping spring the HRA coil. Two of the residues that were neither located at "a" or "d" positions in the heptad repeat nor conserved among the paramyxoviruses were key regulators of the folding and fusion activity of the F protein, showing that residues not expected to be important in coiled-coil formation may play important roles in regulating membrane fusion. Overall, the data support the hypothesis that regions in the F protein that undergo dramatic changes in secondary and tertiary structure between the prefusion and hairpin conformations regulate F protein expression and activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.