ArticleCell regulation1990
Alternative patterns of mitogenesis and cell scattering induced by acidic FGF as a function of cell density in a rat bladder carcinoma cell line.
Article in Cell regulation, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 44 citations in OpenAlex.
- Paracrine FGF1 signaling directs pituitary architecture and size.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Loss of E-cadherin expression is not a prerequisite for c-erbB2-induced epithelial-mesenchymal transition.International journal of oncology · 2014Article
- Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells.The Journal of cell biology · 2000Article
- Evidence for regulated dimerization of cell-cell adhesion molecule (C-CAM) in epithelial cells.The Biochemical journal · 1996Article
- Anti-invasion drugs.Breast cancer research and treatment · 1996Review
- pp60c-src is a positive regulator of growth factor-induced cell scattering in a rat bladder carcinoma cell line.The Journal of cell biology · 1995Article
- Loss of cell surface syndecan-1 causes epithelia to transform into anchorage-independent mesenchyme-like cells.Molecular biology of the cell · 1995Article
- TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.The Journal of cell biology · 1994Article
- Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells.Molecular biology of the cell · 1994Article
- A minority of carcinoma cells producing acidic fibroblast growth factor induces a community effect for tumor progression.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Granulocyte-macrophage and macrophage colony-stimulating factors differentially regulate alpha v integrin expression on cultured human macrophages.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Cyclic AMP distinguishes between two functions of acidic FGF in a rat bladder carcinoma cell line.The Journal of cell biology · 1993Article
- Immunohistochemical detection of acidic fibroblast growth factor in bladder transitional cell carcinoma.Urological research · 1992Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The dual function exerted by acidic fibroblast growth factor (aFGF) in a rat bladder carcinoma cell line has been explored under two different conditions of culture density. At low cell density, aFGF promotes the epithelium-to-mesenchyme transition of NBT-II cells characterized by cell dissociation, morphological changes toward a fibroblastic-like phenotype, and acquisition of cell motility. Under these conditions, NBT-II cells are unresponsive to the growth-promoting effect of aFGF. At high cell density, aFGF is a potent mitogenic factor, but its scattering activity is essentially abrogated. Slight modifications in the binding of aFGF to its specific receptors were observed at high cell density; these changes correlated with a downregulation of receptors with no apparent change in their molecular form. NBT-II cells located at the edge of artificial wounds mimicked the behavior of subconfluent cells, because they did not proliferate upon aFGF treatment. Furthermore, in large-sized NBT-II colonies, peripheral cells were the first to dissociate in response to aFGF. Altogether, our results suggest that the cellular response to multifunctional growth factors might depend on the localization within the responding cell population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.