ArticleJournal of the Royal Society, Interface2007
Mathematical models of the VEGF receptor and its role in cancer therapy.
Article in Journal of the Royal Society, Interface, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Advancing Tumor Treatment Through Artificial Intelligence and Mathematical Modeling: A Comprehensive Review.Health science reports · 2026Article
- Emergence of cyclic hypoxia and the impact of PARP inhibitors on tumor progression.NPJ systems biology and applications · 2024Article
- Applications of Machine Learning (ML) and Mathematical Modeling (MM) in Healthcare with Special Focus on Cancer Prognosis and Anticancer Therapy: Current Status and Challenges.Pharmaceutics · 2024Review
- Quantifying the phosphorylation timescales of receptor-ligand complexes: a Markovian matrix-analytic approach.Open biology · 2018Article
- Multi-scale mathematical modelling of tumour growth and microenvironments in anti-angiogenic therapy.Biomedical engineering online · 2016Article
- Stochastic multi-scale models of competition within heterogeneous cellular populations: Simulation methods and mean-field analysis.Journal of theoretical biology · 2016Article
- Stochastic modelling of the eradication of the HIV-1 infection by stimulation of latently infected cells in patients under highly active anti-retroviral therapy.Journal of mathematical biology · 2016Article
- From invasion to latency: intracellular noise and cell motility as key controls of the competition between resource-limited cellular populations.Journal of mathematical biology · 2016Article
- The effects of intrinsic noise on the behaviour of bistable cell regulatory systems under quasi-steady state conditions.The Journal of chemical physics · 2015Article
- Computational systems biology approaches to anti-angiogenic cancer therapeutics.Drug discovery today · 2015Review
- Noise in cellular signaling pathways: causes and effects.Trends in biochemical sciences · 2012Review
- Dissecting cancer through mathematics: from the cell to the animal model.Nature reviews. Cancer · 2010Review
- Systems biology of vascular endothelial growth factors.Microcirculation (New York, N.Y. : 1994) · 2008Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present an analysis of a stochastic model of the vascular endothelial growth factor (VEGF) receptor. This analysis addresses the contribution of ligand-binding-induced oligomerization, activation of src-homology 2 domain-carrying kinases and receptor internalization in the overall behaviour of the VEGF/VEGF receptor (VEGFR) system. The analysis is based upon a generalization of a Wentzel-Kramers-Brillouin (WKB) approximation of the solution of the corresponding master equation. We predict that tumour-mediated overexpression of VEGFRs in the endothelial cells (ECs) of tumour-engulfed vessels leads to an increased sensitivity of the ECs to low concentrations of VEGF, thus endowing the tumour with increased resistance to anti-angiogenic treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.