ArticleProceedings. Biological sciences2007
Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild.
Article in Proceedings. Biological sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 49 citations in OpenAlex.
- Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field.Ecology letters · 2012Article
- Article
- Mate choice for major histocompatibility complex genetic divergence as a bet-hedging strategy in the Atlantic salmon (Salmo salar).Proceedings. Biological sciences · 2012Article
- Varying disease-mediated selection at different life-history stages of Atlantic salmon in fresh water.Evolutionary applications · 2011Article
- Contrasting responses to selection in class I and class IIα major histocompatibility-linked markers in salmon.Heredity · 2011Article
- Article
- Negative relationships between cellular immune response, Mhc class II heterozygosity and secondary sexual trait in the montane water vole.Evolutionary applications · 2010Article
- Discovery and application of insertion-deletion (INDEL) polymorphisms for QTL mapping of early life-history traits in Atlantic salmon.BMC genomics · 2010Article
- Signals of major histocompatibility complex overdominance in a wild salmonid population.Proceedings. Biological sciences · 2009Article
- Parental relatedness and major histocompatibility effects on early embryo survivorship in Atlantic salmon.Genetica · 2009Article
- MHC standing genetic variation and pathogen resistance in wild Atlantic salmon.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Article
- Major histocompatibility complex (MHC) heterozygote superiority to natural multi-parasite infections in the water vole (Arvicola terrestris).Proceedings. Biological sciences · 2009Article
- MH class IIalpha polymorphism in local and global adaptation of Arctic charr (Salvelinus alpinus L.).Immunogenetics · 2008Article
- Compatibility counts: MHC-associated mate choice in a wild promiscuous primate.Proceedings. Biological sciences · 2008Article
- René Stet's impact on the study of teleost major histocompatibility genes: evolution from loci to populations.Immunogenetics · 2008Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathogen-driven balancing selection is thought to maintain polymorphism in major histocompatibility (MH) genes. However, there have been few empirical demonstrations of selection acting on MH loci in natural populations. To determine whether natural selection on MH genes has fitness consequences for wild Atlantic salmon in natural conditions, we compared observed genotype frequencies of Atlantic salmon (Salmo salar) surviving in a river six months after their introduction as eggs with frequencies expected from parental crosses. We found significant differences between expected and observed genotype frequencies at the MH class II alpha locus, but not at a MH class I-linked microsatellite or at seven non-MH-linked microsatellite loci. We therefore conclude that selection at the MH class II alpha locus was a result of disease-mediated natural selection, rather than any demographic event. We also show that survival was associated with additive allelic effects at the MH class II alpha locus. Our results have implications for both the conservation of wild salmon stocks and the management of disease in hatchery fish. We conclude that natural or hatchery populations have the best chance of dealing with episodic and variable disease challenges if MH genetic variation is preserved both within and among populations.
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