ArticleProceedings. Biological sciences2007
Immunosenescence in some but not all immune components in a free-living vertebrate, the tree swallow.
Article in Proceedings. Biological sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 97 citations in OpenAlex.
- Variations in immune parameters with age in a wild rodent population and links with survival.Ecology and evolution · 2022Article
- Transmissible cancer influences immune gene expression in an endangered marsupial, the Tasmanian devil (Sarcophilus harrisii).Molecular ecology · 2022Article
- Variation in Local and Systemic Pro-Inflammatory Immune Markers of Wild Wood Mice after Anthelmintic Treatment.Integrative and comparative biology · 2019Article
- Evidence of age-related improvement in the foraging efficiency of Adélie penguins.Scientific reports · 2019Article
- Effect of Varying Proportions of Lignin and Cellulose Supplements on Immune Function and Lymphoid Organs of Layer Poultry (The journal of poultry science · 2019Article
- Article
- Immunosenescence patterns differ between populations but not between sexes in a long-lived mammal.Scientific reports · 2017Article
- Supplementing the feeds of layer pullets, at different ages with two different fiber sources improves immune function.Poultry science · 2017Article
- Antibody responses to avian influenza viruses in wild birds broaden with age.Proceedings. Biological sciences · 2016Article
- Eco-immunology and bioinvasion: revisiting the evolution of increased competitive ability hypotheses.Evolutionary applications · 2016Article
- Age-specific haemosporidian infection dynamics and survival in Seychelles warblers.Scientific reports · 2016Article
- Functions of innate and acquired immune system are reduced in domestic pigeons (Columba livia domestica) given a low protein diet.Royal Society open science · 2016Article
- Maternal body size influences offspring immune configuration in an oviparous snake.Royal Society open science · 2016Article
- Host sex and age influence endoparasite burdens in the gray mouse lemur.Frontiers in zoology · 2015Article
- Goat Milk Yoghurt by Using Lacto-B Culture Modulates the Production of Tumor Necrosis Factor-Alpha and Interleukin-10 in Malnourished Rats.Korean journal for food science of animal resources · 2014Article
- Explaining variance of avian malaria infection in the wild: the importance of host density, habitat, individual life-history and oxidative stress.BMC ecology · 2013Article
- Growing old with the immune system: a study of immunosenescence in the zebra finch (Taeniopygia guttata).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2011Article
- Static and dynamic expression of life history traits in the Northern Fulmar (Oikos (Copenhagen, Denmark) · 2011Article
- Ageing in a variable habitat: environmental stress affects senescence in parasite resistance in St Kilda Soay sheep.Proceedings. Biological sciences · 2009Article
- Great tits growing old: selective disappearance and the partitioning of senescence to stages within the breeding cycle.Proceedings. Biological sciences · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A wide diversity of free-living organisms show increases in mortality rates and/or decreases in reproductive success with advancing age. However, the physiological mechanisms underlying these demographic patterns of senescence are poorly understood. Immunosenescence, the age-related deterioration of immune function, is well documented in humans and laboratory models, and often leads to increased morbidity and mortality due to disease. However, we know very little about immunosenescence in free-living organisms. Here, we studied immunosenescence in a free-living population of tree swallows, Tachycineta bicolor, assessing three components of the immune system and using both in vivo and in vitro immunological tests. Immune function in tree swallow females showed a complex pattern with age; acquired T-cell mediated immunity declined with age, but neither acquired nor innate humoral immunity did. In vitro lymphocyte proliferation stimulated by T-cell mitogens decreased with age, suggesting that reduced T-cell function might be one mechanism underlying the immunosenescence pattern of in vivo cell-mediated response recently described for this same population. Our results provide the most thorough description of immunosenescence patterns and mechanisms in a free-living vertebrate population to date. Future research should focus on the ecological implications of immunosenescence and the potential causes of variation in patterns among species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.